{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:31:52Z","timestamp":1784287912136,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,3]]},"abstract":"\n Background<\/jats:title>\n Alzheimer's disease (AD) is a neurodegenerative disorder with progression leading to a decline in cognition. Despite the extensive research, conventional therapies have limited activity and often cause side effects. This demands the need for novel, safer, and effective treatment of AD.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n The objective of this study was to determine the phytochemical constituents and determine the anti-Alzheimer's activity of\n Persicaria hydropiper.<\/jats:italic>\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The total phenol and flavonoid content of the Persicaria (MP) methanol extract was determined, and active principles were identified using GC-MS. The neuroprotective activity was investigated using biochemical assays against A\u03b2\n 1\u201342<\/jats:sub>\n -induced neurodegeneration in SH-SY5Y neuroblastoma cell lines.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Phytochemical analysis revealed the presence of phenols (258.33\u2005mg GAE) and flavonoids (48.31\u2005mg QE). GC-MS identified the anti-inflammatory and antioxidant bioactive compounds. MP exhibited strong ABTS and DPPH radical-scavenging activities and inhibited AChE and BACE1 enzymes. In SHSY5Y cells, MP prevented A\u03b2\n 1\u201342<\/jats:sub>\n aggregation, restored cell morphology, reduced reactive oxygen species levels, and preserved mitochondrial membrane potential. It suppressed A\u03b2 and tau fibrillation, downregulated Bax and Caspase, upregulated Bcl2, Beclin-1, LC3B-II, and LAMP1, and reduced IL-6, TNF-\u03b1, and GSK3\u03b2 expression, indicating potent neuroprotective, antioxidant, and anti-inflammatory effects.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Overall, the results imply that\n Persicaria hydropiper<\/jats:italic>\n exhibits protective activity on neuroblastoma cell lines by mitigating oxidative stress, A\u03b2\/tau fibrils, cell death, and inflammation while also inducing autophagy induced by A\u03b2\n 1\u201342<\/jats:sub>\n . Further\n in vivo<\/jats:italic>\n studies are needed to validate the findings to establish the plant as a potential source of anti-Alzheimer's drug.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13872877261418555","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:28:36Z","timestamp":1770978516000},"page":"821-836","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Persicaria hydropiper<\/i>\n attenuates oxidative stress and reactive oxygen species, and inhibits amyloid-\u03b2\/tau in SH-SY5Y cell lines via multiple pathways of Alzheimer's disease"],"prefix":"10.1177","volume":"110","author":[{"given":"Gali Avinash","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Vel Pharmacy College, VISTAS, Thiruallur, Pallavaram, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paladugu","family":"Pravallika","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vel Pharmacy College, VISTAS, Thiruallur, Pallavaram, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatraman","family":"Thirumalai","sequence":"additional","affiliation":[{"name":"Rajas Dental College and Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5693-2953","authenticated-orcid":false,"given":"Sarad Pawar Naik","family":"Bukke","sequence":"additional","affiliation":[{"name":"Kampala International University, Western Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathange Bharghava Bhushan","family":"Rao","sequence":"additional","affiliation":[{"name":"A.M. 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