{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:10:32Z","timestamp":1778670632195,"version":"3.51.4"},"reference-count":63,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although the molecular basis of Alzheimer's disease (AD) is often studied in Caucasians, its genetic basis in Bangladesh remains elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      We explored the association between single-nucleotide variants (SNVs) of Apolipoprotein E (\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      ) and other genes for AD risk among Bangladeshis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited AD patients and controls aged \u226518 years and conducted next generation sequencing (NGS) to analyze \u223c30\u2005Mb of the human exome. The NGS targets \u223c99% of the Consensus Coding Sequence and RefSeq annotations, along with the complete mitochondrial genome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 132 (72 AD: 60 control) age- and sex-matched participants were sequenced. The average age of AD was comparable to that of controls (64.5\u2009\u00b1\u200911.3 versus 63.6\u2009\u00b1\u20099.8, p\u2009=\u20090.69), and the gender distribution (p\u2009=\u20090.49) was similar between the study groups. Following NGS analysis 23 SNVs from 16 potential genes were identified. The\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      variant rs429358 was associated with a significantly increased age- and sex- adjusted risk of AD (OR) 8.0 (95% CI: 2.3\u201327.9, p\u2009=\u20090.001) in the additive model, 10.5 (95% CI: 2.8\u201339.5, p\u2009&lt;\u20090.001) in the dominant model, and 6.9 (95% CI: 1.8\u201326.9, p\u2009=\u20090.005) in the heterozygous genotype model, as determined using the Bonferroni adjustment method. The top SNV for predicting AD was the\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      variant rs429358 with a -logP value of 3, followed by\n                      <jats:italic toggle=\"yes\">BDNF<\/jats:italic>\n                      gene variant rs6265 at 1.3, and\n                      <jats:italic toggle=\"yes\">CR1<\/jats:italic>\n                      gene variant rs1349409945 at 1.2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      variant rs429358 is linked to an 8-fold increased risk of AD among Bangladeshis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261419066","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T05:32:29Z","timestamp":1771911149000},"page":"760-768","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Next-generation sequencing study identifies the first genes associated with Alzheimer's disease in Bangladeshi population: The CARED study"],"prefix":"10.1177","volume":"110","author":[{"given":"Maliha","family":"Hakim","sequence":"first","affiliation":[{"name":"National Institute of Neurosciences and Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-5023","authenticated-orcid":false,"given":"Redoy","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Royal Holloway University of London"},{"name":"Department of Cardiac Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gie","family":"Ken-Dror","sequence":"additional","affiliation":[{"name":"Royal Holloway University of London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Abdullah","family":"Yusuf","sequence":"additional","affiliation":[{"name":"National Institute of Neurosciences and Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Nur","family":"Uddin","sequence":"additional","affiliation":[{"name":"National Institute of Neurosciences and Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mim Tanzila","family":"Mamun","sequence":"additional","affiliation":[{"name":"Department of Medicine, Chottogram Army Medical College, Chittagong, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alif","family":"Al Mamun","sequence":"additional","affiliation":[{"name":"Macquarie University"},{"name":"Department of Education, Southern Cross University, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam","family":"Kawnayn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Combined Military Hospital, Chittagong, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Sharma","sequence":"additional","affiliation":[{"name":"Royal Holloway University of London"},{"name":"Department of Clinical Neuroscience, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12694"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-022-00338-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006239"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.937486"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pu.13.050192.002243"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610209991505"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.118.218057"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12901"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5113"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.07.001"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-024-00136-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191212"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12450"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2174\/1567205017666200102144640"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cb3e25"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389201023666220208093919"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells14040243"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.17666"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2021.10.007"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1934"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.439"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12212512"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12719"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13655"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0150-6"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac125"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210145"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14553"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fdgth.2020.00014"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70014"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220025"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13113"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glad057"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02089-w"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00789-z"},{"key":"e_1_3_3_39_2","article-title":"Correlation of cognitive status and atrophy score in Alzheimer\u2019s disease among the Bangladeshi population","volume":"16","author":"Hakim M","year":"2024","unstructured":"Hakim M, Islam M, Hossain M, et al. Correlation of cognitive status and atrophy score in Alzheimer\u2019s disease among the Bangladeshi population. Cureus 2024; 16: e65833.","journal-title":"Cureus"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lansea.2023.100257"},{"key":"e_1_3_3_41_2","unstructured":"American College of Radiology. ACR Appropriateness Criteria\u00ae Dementia. [Jul; 2024]. 2020."},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.10.967"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2205-4"},{"key":"e_1_3_3_44_2","article-title":"Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI)","volume":"7","author":"Arevalo-Rodriguez I","year":"2021","unstructured":"Arevalo-Rodriguez I, Smailagic N, Roqu\u00e9-Figuls M, et al. Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev 2021; 7: CD010783.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1222"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1229"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-021-01171-4"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.52"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1159\/000321984"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2023.110670"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30412-9"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00574-4"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-018-0413-4"},{"key":"e_1_3_3_54_2","article-title":"Genetic and regulatory architecture of Alzheimer's disease in the APOE region","volume":"12","author":"Kulminski AM","year":"2020","unstructured":"Kulminski AM, Shu L, Loika Y, et al. Genetic and regulatory architecture of Alzheimer's disease in the APOE region. Alzheimers Dement (Amst) 2020; 12: e12008.","journal-title":"Alzheimers Dement (Amst)"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1035885"},{"key":"e_1_3_3_56_2","article-title":"Association of rs6265 and rs2030324 polymorphisms in brain-derived neurotrophic factor gene with Alzheimer's disease: a meta-analysis","volume":"9","author":"Lin Y","year":"2014","unstructured":"Lin Y, Cheng S, Xie Z, et al. Association of rs6265 and rs2030324 polymorphisms in brain-derived neurotrophic factor gene with Alzheimer's disease: a meta-analysis. PLoS One 2014; 9: e94961.","journal-title":"PLoS One"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.12.023"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.194"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.24"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182452b40"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8723-8"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.4103\/0971-6866.45000"},{"key":"e_1_3_3_63_2","first-page":"135","article-title":"APOE4 Allele in north Indian elderly patients with dementia or late onset depression-a multiple-disease case control study","volume":"8","author":"Misra A","year":"2019","unstructured":"Misra A, Chakrabarti SS, Gambhir IS, et al. APOE4 Allele in north Indian elderly patients with dementia or late onset depression-a multiple-disease case control study. Mol Biol Res Commun 2019; 8: 135\u2013140.","journal-title":"Mol Biol Res Commun"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1159\/000350872"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261419066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261419066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261419066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:21:27Z","timestamp":1778667687000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261419066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1177\/13872877261419066"],"URL":"https:\/\/doi.org\/10.1177\/13872877261419066","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]}}}