{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:11:59Z","timestamp":1783944719425,"version":"3.55.0"},"reference-count":76,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100023885","name":"All of Us Research Program","doi-asserted-by":"publisher","award":["R01 AG37491-15"],"award-info":[{"award-number":["R01 AG37491-15"]}],"id":[{"id":"10.13039\/100023885","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>TAR DNA-binding protein 43 (TDP-43) proteinopathy contributes to Alzheimer's disease progression, but diagnosis remains autopsy-dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to develop a predictive model using FDG-PET imaging to identify brain regions associated with TDP-43 pathology in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Penalized logistic regression analyzed data from 294 participants and a subset of 159 with Braak and Thal \u22654. Features included FDG standard uptake value ratios (SUVRs) from 123 brain regions and age. Participants were split into training (90%) and testing (10%) datasets, with significant predictors identified by non-zero coefficients at optimal lambda.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The model achieved 68% accuracy (AUC\u2009=\u20090.70) in 294 participants, highlighting the middle temporal gyrus, parahippocampal gyrus, and hippocampus. In the subset (n\u2009=\u2009159), accuracy was 65% (AUC\u2009=\u20090.71), with the medial amygdala and precentral gyrus as key predictors of TDP-43 pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests a moderate predictive accuracy of FDG-PET to identify brain regions associated with Alzheimer's disease-related TDP-43 proteinopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261421241","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:41:17Z","timestamp":1773412877000},"page":"1086-1098","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["FDG-PET imaging to identify brain regions associated with Alzheimer's disease-related TDP-43 proteinopathy: A predictive model using penalized logistic regression analysis"],"prefix":"10.1177","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7521-7082","authenticated-orcid":false,"given":"Anna","family":"Lavrova","sequence":"first","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Satoh","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirubol","family":"Tosakulwong","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Weigand","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aivi T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Ross","family":"Reichard","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Prudencio","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Petrucelli","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val","family":"Lowe","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Whitwell","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-8634","authenticated-orcid":false,"given":"Keith A.","family":"Josephs","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.09.004"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.093"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24493"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww224"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12424"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000304041.09418.b1"},{"key":"e_1_3_3_8_2","first-page":"804","article-title":"Varied effects of age-related neuropathologies on the trajectory of late life cognitive decline","volume":"140","author":"Boyle PA","year":"2017","unstructured":"Boyle PA, Yang J, Yu L, et al. Varied effects of age-related neuropathologies on the trajectory of late life cognitive decline. Brain 2017; 140: 804\u2013812.","journal-title":"Brain"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.3961"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30284-3"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1269-z"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02937-4"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy049"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.102954"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa299"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-024-03502-z"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.058977"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13808"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12312-5"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12763"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy049"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009722"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.007"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0127-z"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318142774e"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.4.479"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0237-2"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww214"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1537-1"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0400-4"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293396"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318292492a"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0072-9752(07)01253-5"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90168-6"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm336"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw157"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2024.120509"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v033.i01"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1211-9"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000225908.90052.07"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.12.1915"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2021.11.2416"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030573"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003610"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2009.01017.x"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21154"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.09.048"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.10.032"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15603"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70568"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02434-3"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.077371"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-023-02653-2"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201166"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02444-1"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-221094"},{"key":"e_1_3_3_61_2","first-page":"22","article-title":"Molecular fragment characteristics and distribution of tangle associated TDP-43 (TATs) and other TDP-43 lesions in Alzheimer's disease","volume":"4","author":"Josephs KA","year":"2023","unstructured":"Josephs KA, Koga S, Tosakulwong N, et al. Molecular fragment characteristics and distribution of tangle associated TDP-43 (TATs) and other TDP-43 lesions in Alzheimer's disease. Free Neuropathol 2023; 4: 22.","journal-title":"Free Neuropathol"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00934-5"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1159\/000116984"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-018-0300-0"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26762"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15450"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5824"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.08.008"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.02.052"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nly049"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106412"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.66"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1154-1"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlad085"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809462200"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900688106"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.263194"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261421241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261421241","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261421241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:43:22Z","timestamp":1783943002000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261421241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/13872877261421241"],"URL":"https:\/\/doi.org\/10.1177\/13872877261421241","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]}}}