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Disease"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Plasma biomarkers for Alzheimer's disease (AD) studies, but much remains unknown about the associations of plasma and PET biomarkers of amyloid-\u03b2 (A\u03b2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the associations of plasma A\u03b2 with PET A\u03b2 accumulation and progression from PET A- to A\u2009+\u2009.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated PET A- participants with baseline plasma A\u03b2 measurements and longitudinal indices of PET A\u03b2. Linear mixed effects models characterized the association of plasma biomarker outcomes with changes in PET A\u03b2 values. Survival analysis evaluated the ability of baseline plasma biomarker A+\/- status to differentiate trajectories of progression from PET A- to A\u2009+\u2009.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Linear mixed effects models showed significant interactions between time and plasma A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      with respect to longitudinal measures of PET A\u03b2 burden. Survival analysis found that A status determined from plasma A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      predicted distinct patterns of progression from PET A- to A\u2009+\u2009.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These models suggest that, in PET A- participants, baseline plasma A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      can be used to predict both how much A\u03b2 will accumulate over time and likelihood of becoming PET A\u2009+\u2009.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261422406","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:09:16Z","timestamp":1773234556000},"page":"1166-1174","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Plasma amyloid-\u03b2 predicts amyloid-\u03b2 accumulation in PET A- non-demented participants"],"prefix":"10.1177","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-1715","authenticated-orcid":false,"given":"Alexandra","family":"Gogola","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Lopresti","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos D.","family":"Ikonomovic","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"},{"name":"University of Pittsburgh School of Medicine"},{"name":"Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Snitz","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Tudorascu","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Reese","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zeng","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davneet","family":"Minhas","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kofler","sequence":"additional","affiliation":[{"name":"University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristy","family":"Matan","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Aizenstein","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Lopez","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Karikari","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"255","article-title":"Clinical development of aducanumab, an anti-A\u03b2 human monoclonal antibody being investigated for the treatment of early Alzheimer's disease","volume":"4","author":"Budd Haeberlein S","year":"2017","unstructured":"Budd Haeberlein S, O'Gorman J, Chiao P, et al. 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