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The Montreal Cognitive Assessment (MoCA) and the Alzheimer's Disease Assessment Scale-Cog-13 item (ADAS-Cog-13) are common screeners that provide insight into early dementia progression. However, how these tools relate to biomarkers and psychological predictors before formal diagnosis is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study examines associations between biological and psychological factors with MoCA and ADAS-Cog-13 scores to guide clinicians in selecting the most informative screener for specific dementia risk profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Zero-order correlations and Classification and Regression Trees were conducted using data from the ADNI-DOD database, comprising high-risk veterans without baseline dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MoCA scores were primarily associated with biomarker predictors and depression, whereas ADAS-Cog-13 scores were primarily associated with post-traumatic stress disorder diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cognitive screeners tailored to brief psychological and medical histories may improve early detection of cognitive decline and Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261424407","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:30:01Z","timestamp":1773225001000},"page":"1640-1653","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential associations of cognitive screeners with biological, psychological, and cognitive factors in high-risk older adults"],"prefix":"10.1177","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3122-8838","authenticated-orcid":false,"given":"Michaela","family":"Rice","sequence":"first","affiliation":[{"name":"Colorado State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8962-7613","authenticated-orcid":false,"given":"Kathleen Angela","family":"Willoughby-Dudley","sequence":"additional","affiliation":[{"name":"Colorado State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengting","family":"Lin","sequence":"additional","affiliation":[{"name":"Colorado State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haonan","family":"Wang","sequence":"additional","affiliation":[{"name":"Colorado State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2727-3634","authenticated-orcid":false,"given":"Deana B.","family":"Davalos","sequence":"additional","affiliation":[{"name":"Colorado State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative *","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504327"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30403-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06624-y"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-200245"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_3_7_2","first-page":"1436","article-title":"Dementia still diagnosed too late \u2014 data from the Czech Republic","volume":"43","author":"Luzny J","year":"2014","unstructured":"Luzny J, Holmerova I, Wija P, et al. 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