{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:14:30Z","timestamp":1783415670669,"version":"3.54.6"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"All India Institute of Medical Sciences, New Delhi","award":["F.8.55\/AC-55\/2023\/RS"],"award-info":[{"award-number":["F.8.55\/AC-55\/2023\/RS"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    Automated cerebrospinal fluid (CSF) biomarkers have been underexplored in early onset dementias (EOD) within the South-Asian context. In our ongoing ASCEND cohort (tertiary care center in India), we evaluated the added value of incorporating CSF amyloid-\u03b2 1-42 (A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    ) and phosphorylated tau 181 (p-Tau181) (Elecsys immunoassay) into existing clinical diagnostic algorithms for EOD. Among 61 participants (mean age: 56.3\u202f\u00b1\u202f5.8 years; 55.7% females), the CSF p-Tau181\/A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    ratio revealed alternative etiology in 16% of cases [5\/37 (13.5%) clinically probable AD were reclassified as non-AD after CSF, while 5\/24 (20.8%) clinically non-AD dementias were reclassified as AD]. Notably, clinico-biological concordance varied across different phenotypic presentations.\n                  <\/jats:p>","DOI":"10.1177\/13872877261426905","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:23:44Z","timestamp":1773228224000},"page":"142-148","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical relevance of automated cerebrospinal fluid amyloid and tau biomarkers in Indian patients with early onset cognitive decline: Insights from the AIIMS-Delhi Study Cohort of Early\/late oNset Dementia (ASCEND)"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0095-6569","authenticated-orcid":false,"given":"Anu","family":"Gupta","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Anjali","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Adhya","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darpan","family":"Vetal","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Dubey","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6418-8928","authenticated-orcid":false,"given":"Prabhakar","family":"Tiwari","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh","family":"Gaikwad","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopa","family":"Rajan","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venugopalan Y","family":"Vishnu","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamta Bhushan","family":"Singh","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Bhatia","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-7947","authenticated-orcid":false,"given":"Achal K","family":"Srivastava","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavi","family":"Tripathi","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmy","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari","family":"Tripathi","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31824b211b"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30440-3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-025-01123-5"},{"key":"e_1_3_3_6_2","article-title":"Clinical application of CSF biomarkers for Alzheimer's disease: from rationale to ratios","volume":"14","author":"Bouwman FH","year":"2022","unstructured":"Bouwman FH, Frisoni GB, Johnson SC, et al. 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