{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:15:35Z","timestamp":1778166935002,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100015539","name":"The Australian Government","doi-asserted-by":"crossref","award":["Research Training Program (RTP) Scholarship"],"award-info":[{"award-number":["Research Training Program (RTP) Scholarship"]}],"id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000943","name":"Commonwealth Scientific and Industrial Research Organisation","doi-asserted-by":"publisher","award":["postgraduate studentship program"],"award-info":[{"award-number":["postgraduate studentship program"]}],"id":[{"id":"10.13039\/501100000943","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Habitual daytime napping is a significant aspect of many older adults\u2019 sleep-wake cycle. Growing evidence links napping and cognition in the context of Alzheimer's disease (AD), yet little is known about how genetic risk influences this relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates interactions between genetic risk for AD and napping on cognition in 1655 cognitively healthy middle-aged to older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Cognition was assessed using a self-administered online battery and reduced to three variables: memory, visuospatial abilities and executive functions. Genetic risk was assessed with the presence of\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u025b4 allele and polygenic risk scores for AD (PRS; excluding\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      ). ANCOVA assessed interactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a significant interaction between\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u025b4 and napping duration on the memory component (\n                      <jats:italic toggle=\"yes\">F<\/jats:italic>\n                      (2,1645)\u2009=\u20093.84,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.022, \u03b7p\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.005).\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u025b4 carriers reporting long naps demonstrated better memory than non-carriers also reporting long naps. Among\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u025b4 carriers, those who napped for \u2265 1\u2005h performed better than those reporting shorter naps. In a separate analysis, there was a significant interaction between PRS and napping (\n                      <jats:italic toggle=\"yes\">F<\/jats:italic>\n                      (2653)\u2009=\u20093.44,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.033, \u03b7p\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.010). Low PRS was related to better memory than high PRS among those who did not nap. Within the low PRS group, participants who did not nap outperformed those reporting short naps. Results remained significant after accounting for overnight sleep efficiency.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings suggest that the relationship between napping and memory may vary as a function of genetic risk for AD. Results could inform studies looking into personalized preventative treatment based on genetic profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261427707","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:23:36Z","timestamp":1773411816000},"page":"1741-1751","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship between napping and memory varies as a function of genetic risk for Alzheimer's disease"],"prefix":"10.1177","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9154-9158","authenticated-orcid":false,"given":"Caroline","family":"Faucher","sequence":"first","affiliation":[{"name":"University of Newcastle, Newcastle, NSW, Australia"},{"name":"Australian eHealth Research Centre, CSIRO Health and Biosecurity, Brisbane, Qld, Australia"},{"name":"QIMR Berghofer Medical Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Thienel","sequence":"additional","affiliation":[{"name":"School of Public Health and Medicine, College of Health Medicine and Wellbeing, University of Newcastle, Newcastle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7129-7006","authenticated-orcid":false,"given":"Anna","family":"Behler","sequence":"additional","affiliation":[{"name":"University of Newcastle, Newcastle, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5378-3948","authenticated-orcid":false,"given":"Lina","family":"Gomez","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurgen","family":"Fripp","sequence":"additional","affiliation":[{"name":"Australian eHealth Research Centre, CSIRO Health and Biosecurity, Brisbane, Qld, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Breakspear","sequence":"additional","affiliation":[{"name":"University of Newcastle, Newcastle, NSW, Australia"},{"name":"School of Public Health and Medicine, College of Health Medicine and Wellbeing, University of Newcastle, Newcastle, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7274-7299","authenticated-orcid":false,"given":"Michelle K.","family":"Lupton","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute"},{"name":"School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia"},{"name":"School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.937486"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828726f5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00404-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01024-z"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201606"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02931-w"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.10.002"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.02.003"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00740-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220025"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-00934-y"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131058"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2018.03.025"},{"key":"e_1_3_3_17_2","article-title":"Sleep, cognitive impairment, and Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"40","author":"Bubu OM","year":"2016","unstructured":"Bubu OM, Brannick M, Mortimer J, et al. 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