{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:18:11Z","timestamp":1778167091372,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"UJISABIO","award":["UJISABIO22_PI01"],"award-info":[{"award-number":["UJISABIO22_PI01"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) has been reported to be associated with changes in inflammatory levels, although further research is needed. This study focused on identifying specific inflammatory biomarkers in peripheral blood that could differentiate patients with AD from healthy control subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The primary objective was to determine whether a selection of peripheral blood inflammatory biomarkers could serve as a diagnostic tool for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A multicenter study was conducted, comparing 39 patients with AD to 27 healthy controls. AD diagnosis was confirmed through a comprehensive evaluation, including the Mini-Mental State Examination and analysis of cerebrospinal fluid or positron emission tomography. Thirteen inflammatory markers were measured, and logistic regression analysis was used to assess their discriminatory potential. The relationship between the\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      genotype and biomarker levels was also examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analysis revealed that interleukin-8 (IL-8), platelet-derived growth factor (PDGF-AB\/BB), and interleukin-12p40 (IL-12p40) were the most significant markers. IL-8 levels showed a strong correlation with disease status, being notably lower in AD patients compared to controls. Furthermore, the levels of these three markers were associated with the patient's amyloid-positive status of the\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      genotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These results suggest that reduced levels of IL-8 in the blood could be a promising biomarker for the diagnosis of AD. Additionally, inflammatory biomarkers such as IL-8 and IL-12p40 may be linked to the amyloid pathology of the\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      genotype in AD patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261428052","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:32:53Z","timestamp":1773225173000},"page":"1778-1792","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Decreased interleukin-8 levels in the peripheral blood of Alzheimer's disease patients"],"prefix":"10.1177","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9072-929X","authenticated-orcid":false,"given":"Francisco","family":"Ros","sequence":"first","affiliation":[{"name":"Universitat Jaume I"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2537-2156","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"Mart\u00ednez Lozano","sequence":"additional","affiliation":[{"name":"Hospital La Magdalena"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Arnau","sequence":"additional","affiliation":[{"name":"Hospital La Magdalena"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4351-3955","authenticated-orcid":false,"given":"Jacobo","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"FISABIO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7567-8021","authenticated-orcid":false,"given":"Alejandro","family":"Vericat","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Castell\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-4734","authenticated-orcid":false,"given":"Rafael","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Hospital Arnau de Vilanova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-4234","authenticated-orcid":false,"given":"Javier S","family":"Burgos","sequence":"additional","affiliation":[{"name":"Universitat Jaume I"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317134"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-024-02790-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1653"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00456"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.03.007"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316201"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00124-X"},{"key":"e_1_3_3_10_2","first-page":"2740","article-title":"Microglial activation correlates in vivo with both tau and amyloid in Alzheimer\u2019s disease","volume":"141","author":"Dani M","year":"2018","unstructured":"Dani M, Wood M, Mizoguchi R, et al. 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