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Early studies suggested that 40\u2005Hz visual flicker entrains gamma activity and reduces amyloid pathology; however, later work found either absent entrainment or even increased amyloid burden, revealing strong dependence on disease stage, network integrity, and stimulation parameters. Initial clinical investigations suggest that 40\u2005Hz stimulation is safe, well-tolerated, and capable of modulating cortical network dynamics and improving cognition, despite limited effects on amyloid burden. 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