{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:31:57Z","timestamp":1785807117544,"version":"3.56.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dementia is an escalating global public health concern, with Alzheimer's disease accounting for the largest proportion of cases. However, evidence on its association with lipid abnormalities remains limited in low- and middle-income countries, particularly in sub\u2013Saharan Africa<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association between lipid profile parameters and dementia risk among older adults in Ghana.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cross-sectional study was conducted using records from 16 individuals diagnosed with dementia and 28 age-matched controls. Lipid levels including total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, non-HDL cholesterol, and coronary risk index, were analyzed using descriptive statistics and binary logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dementia cases had higher median levels of total cholesterol (5.29 versus 4.69\u2005mmol\/L), triglycerides (1.20 versus 0.86\u2005mmol\/L), low-density lipoprotein (3.38 versus 2.75\u2005mmol\/L), non-HDL cholesterol (3.89 versus 3.23\u2005mmol\/L), and coronary risk index (5.18 versus 3.15) compared to controls. Elevated coronary risk was strongly associated with dementia (aOR\u2009=\u200913.87, p\u2009=\u20090.010), indicating a markedly increased likelihood of cognitive impairment among individuals with higher cardiovascular risk. However, none of the individual lipid levels remained significant after adjustment for hypertension and the potential confounding effects of each lipid parameter on the others.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall cardiovascular risk, rather than isolated lipid markers, appears more relevant in dementia risk assessment among older Ghanaian adults. Early evaluation and management of coronary risk may play a critical role in dementia prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261430772","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:37:36Z","timestamp":1773250656000},"page":"167-173","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between lipid levels and dementia risk among older Ghanaian adults"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6365-5213","authenticated-orcid":false,"given":"Foster","family":"Appiah","sequence":"first","affiliation":[{"name":"College of Health and Allied Sciences, University of Cape Coast"},{"name":"Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Nalerigu Nursing and midwifery college, Nalerigu, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Larbi","family":"Simpong","sequence":"additional","affiliation":[{"name":"College of Health and Allied Sciences, University of Cape Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Marfo","sequence":"additional","affiliation":[{"name":"College of Health and Allied Sciences, University of Cape Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Nkrumah","family":"Osei","sequence":"additional","affiliation":[{"name":"College of Health and Allied Sciences, University of Cape Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell Hubert","family":"Antwi","sequence":"additional","affiliation":[{"name":"College of Health and Allied Sciences, University of Cape Coast"},{"name":"Department of Medical Laboratory Science, Faculty of Health Sciences, Koforidua Technical University, Koforidua, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwaku Sarfo","family":"Manu","sequence":"additional","affiliation":[{"name":"Alzheimer's and Related Disorders Association of Ghana, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Dogah","sequence":"additional","affiliation":[{"name":"College of Health and Allied Sciences, University of Cape Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1173-1493","authenticated-orcid":false,"given":"Ansumana","family":"Bockarie","sequence":"additional","affiliation":[{"name":"University of Cape Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"84","article-title":"The global impact of dementia: an analysis of prevalence, incidence, cost and trends","volume":"2015","author":"Prince M","year":"2015","unstructured":"Prince M, Wimo A, Guerchet M, et al. 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