{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:25:40Z","timestamp":1790645140812,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postoperative delirium (POD) affects up to a third of older surgical patients, leading to significant morbidity, mortality, and potential progression to Alzheimer's disease (AD). Polygenic risk scores (PRS) capture inherited susceptibility to complex diseases, but their relevance to POD is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We examined whether higher AD-PRS predict increased POD risk in patients without dementia and whether sleep burden modifies this relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included 345 414 UK Biobank participants (mean [\n                      <jats:italic toggle=\"yes\">SD<\/jats:italic>\n                      ] age: 70.1 [7.9], range: 40.4\u201387.6 years; 54.0% women) to identify new-onset POD, using the International Classification of Disease-10 coding within three days of surgery. Participants with mild cognitive impairment, dementia, or dementia diagnosed within one year of POD were excluded. AD-PRS was calculated as a weighted sum of genetic variants, with scores divided into quartiles due to the absence of standardized thresholds. Covariates included demographics, comorbidities, and lifestyle factors. Cox proportional hazard models were used to evaluate the relationship between AD-PRS and POD risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1610 POD cases were identified. Compared to Q1, individuals in Q3 (HR\u2009=\u20091.23, 95% CI [1.07\u20131.42],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and Q4 (1.35, [1.18\u20131.56],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) had progressively higher POD risk. Findings were consistent across alternate POD definitions and subgroups defined by sleep burden, sex, age, cardiovascular risk, and inflammatory markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher AD-PRS is independently associated with greater POD risk in adults without dementia. AD genetic susceptibility may help identify high-risk surgical patients and warrants validation in prospective perioperative cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261430955","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:54:26Z","timestamp":1773665666000},"page":"240-248","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations between polygenic risk scores for Alzheimer's disease and postoperative delirium risk"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3935-8841","authenticated-orcid":false,"given":"Yun Jin","family":"Chen","sequence":"first","affiliation":[{"name":"Queen's University School of Medicine"},{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1277-3055","authenticated-orcid":false,"given":"Arlen","family":"Gaba","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"},{"name":"Tufts Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6847-3272","authenticated-orcid":false,"given":"Hui-Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"Tzu Chi University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Maher","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2233-1065","authenticated-orcid":false,"given":"Richa","family":"Saxena","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4684-4909","authenticated-orcid":false,"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"},{"name":"Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0350-3132","authenticated-orcid":false,"given":"Kun","family":"Hu","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"},{"name":"Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1476-1460","authenticated-orcid":false,"given":"Lei","family":"Gao","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"},{"name":"Massachusetts General Hospital"},{"name":"Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.10.019"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-022-03049-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2273"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-019-05172-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5088"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00698-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.12.023"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000278905.07899.df"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.09.080"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2014.12.192"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcorm.2024.100401"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24082-z"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.07.018"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab272"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003400"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-080796"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00921-z"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09718-5"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007136"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16853"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2021.12.002"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.018483"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab272"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26617"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032086"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231627"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14913"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/81.3.515"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-90277-9"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01206-9"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.005"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00101-5"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005487"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318298b077"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1732"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2023.105204"},{"key":"e_1_3_3_39_2","article-title":"Polygenic score modifies risk for Alzheimer\u2019s disease in APOE \u03b54 homozygotes at phenotypic extremes","volume":"13","author":"Huq AJ","year":"2021","unstructured":"Huq AJ, Fulton-Howard B, Riaz M, et al. Polygenic score modifies risk for Alzheimer\u2019s disease in APOE \u03b54 homozygotes at phenotypic extremes. Alzheimers Dement 2021; 13: e12226.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2025.05.014"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S87888"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.4097\/kja.23301"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0375-9393.18.12400-X"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0321025"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1177\/2151458513504215"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261430955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261430955","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261430955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:24:03Z","timestamp":1783412643000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261430955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,16]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/13872877261430955"],"URL":"https:\/\/doi.org\/10.1177\/13872877261430955","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,16]]}}}