{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:08:45Z","timestamp":1783814925842,"version":"3.55.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Nancy and the Buster Alvord Endowed Chair in Neuropathology"},{"name":"NIH","award":["P30AG066509"],"award-info":[{"award-number":["P30AG066509"]}]},{"name":"NIH","award":["R01AG087226"],"award-info":[{"award-number":["R01AG087226"]}]},{"name":"NIH","award":["R03AG05107"],"award-info":[{"award-number":["R03AG05107"]}]},{"name":"NIH","award":["R21AG073676"],"award-info":[{"award-number":["R21AG073676"]}]},{"name":"NIH","award":["U19AG066567"],"award-info":[{"award-number":["U19AG066567"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Amyloid-\u03b2 (A\u03b2) can deposit in or near the microvascular basement membrane (BM) in Alzheimer's disease (AD). We examined the effect of the A\u03b2 binding antibody, lecanemab, on BM collagen IV (Col-IV) using viable brain microvessels (MV) isolated from human postmortem brain tissue with high AD neuropathologic change (ADNC=3, 16 females (mean 86 years), 11 males (mean 81 years)). MVs were exposed to lecanemab or isotype for 4 days and examined for Col-IV related outcomes: western blotting, capillary electrophoresis, RT-PCR, and degraded Col-IV. We find a subset of MV from some donors demonstrate Col-IV changes that could cause microvascular injury when exposed to lecanemab.<\/jats:p>","DOI":"10.1177\/13872877261433167","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T13:55:23Z","timestamp":1774014923000},"page":"530-536","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lecanemab alters basement membrane collagen IV in viable microvessels isolated from brains with high Alzheimer's disease neuropathology"],"prefix":"10.1177","volume":"111","author":[{"given":"Mamatha","family":"Damodarasamy","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA, USA"},{"name":"Veterans Affairs Puget Sound Health Care System, Geriatric Research Education and Clinical Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo J.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Dirk","family":"Keene","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin S.","family":"Latimer","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"MacCoss","sequence":"additional","affiliation":[{"name":"Department of Genome Sciences, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Banks","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA, USA"},{"name":"Veterans Affairs Puget Sound Health Care System, Geriatric Research Education and Clinical Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA, USA"},{"name":"Veterans Affairs Puget Sound Health Care System, Geriatric Research Education and Clinical Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6917-9286","authenticated-orcid":false,"given":"May J.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA, USA"},{"name":"Veterans Affairs Puget Sound Health Care System, Geriatric Research Education and Clinical Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0297-y"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-024-00704-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2025.04.003"},{"key":"e_1_3_3_5_2","first-page":"19","article-title":"Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue","volume":"3","author":"Love S","year":"2014","unstructured":"Love S, Chalmers K, Ince P, et al. Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue. Am J Neurodegener Dis 2014; 3: 19\u201332.","journal-title":"Am J Neurodegener Dis"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad188"},{"key":"e_1_3_3_7_2","article-title":"ARIA In patients treated with lecanemab (BAN2401) in a phase 2 study in early Alzheimer's disease","volume":"9","author":"Honig LS","year":"2023","unstructured":"Honig LS, Barakos J, Dhadda S, et al. ARIA In patients treated with lecanemab (BAN2401) in a phase 2 study in early Alzheimer's disease. Alzheimers Dement (N Y) 2023; 9: e12377.","journal-title":"Alzheimers Dement (N Y)"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac021"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-022-01308-6"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180797"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2021.104282"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0910-3"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.TIR119.001616"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-024-00581-1"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70103"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12045"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.618986"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194458"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70882"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.06.004"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.1.1"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65616-7"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.11.7172"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4547(20001101)62:3<451::AID-JNR15>3.0.CO;2-F"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0816"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01140"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.14897"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.5.801"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.933872"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102786"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2007.05.005"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00335-1"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2025.e00570"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.09.028"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-19-07724.2001"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610210000827"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031413"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17740793"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/bit.27224"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261433167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261433167","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261433167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T08:51:45Z","timestamp":1779180705000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261433167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/13872877261433167"],"URL":"https:\/\/doi.org\/10.1177\/13872877261433167","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,20]]}}}