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Wang et al. examined sex-specific tau propagation across Braak neurofibrillary tangle stages in an Alzheimer's Disease Neuroimaging Initiative cohort, while considering cognitive and amyloid status, using longitudinal tau-PET imaging. They found that females exhibit faster tau spread and accelerated clinical decline in advanced stages. While the study offers valuable insights, factors such as neuroimaging-pathology discordance, coexisting conditions, and limited cohort diversity warrant caution before making broad generalizations. Nonetheless, these findings highlight sex-dependent AD trajectories and reinforce the need for precision medicine and timely, individualized interventions to improve outcomes and address biological variability in disease progression.<\/jats:p>","DOI":"10.1177\/13872877261433219","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:06:01Z","timestamp":1774857961000},"page":"537-540","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of sex on tau distribution across Braak stages in the Alzheimer's disease spectrum"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2170-6662","authenticated-orcid":false,"given":"Rodolfo G.","family":"Gatto","sequence":"first","affiliation":[{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8876-8038","authenticated-orcid":false,"given":"Hossam","family":"Youssef","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/frdem.2025.1706177"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.04.016"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.020"},{"key":"e_1_3_3_5_2","article-title":"In vivo network models identify sex differences in the spread of tau pathology across the brain","volume":"12","author":"Shokouhi S","year":"2020","unstructured":"Shokouhi S, Taylor WD, Albert K, et al. 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