{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:35:07Z","timestamp":1788345307061,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003750","name":"Association France Alzheimer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002790","name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    A recent case study reported a\n                    <jats:italic toggle=\"yes\">PSEN2<\/jats:italic>\n                    mutation carrier with high amyloid burden but unexpectedly restricted tau pathology and preserved cognition. While genetic and proteomic factors were explored, the patient's lifelong occupational heat exposure may represent an overlooked contributor to resilience. We highlight evidence from preclinical, clinical, and epidemiological studies suggesting that elevated body temperature promotes tau clearance\n                    <jats:italic toggle=\"yes\">via<\/jats:italic>\n                    enhanced proteostasis. This observation invites deeper investigation into thermoregulation as a modifiable factor in tau homeostasis and Alzheimer's disease vulnerability, with implications for both biomarker interpretation and therapeutic strategies targeting tau-mediated neurodegeneration.\n                  <\/jats:p>","DOI":"10.1177\/13872877261433226","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:25:51Z","timestamp":1773840351000},"page":"541-544","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Lifelong heat exposure as a potential contributor to Alzheimer's disease resilience"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7291-4512","authenticated-orcid":false,"given":"Geoffrey","family":"Canet","sequence":"first","affiliation":[{"name":"Institut de G\u00e9nomique Fonctionnelle, Universit\u00e9 de Montpellier, CNRS, INSERM, Montpellier, 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