{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:10:06Z","timestamp":1779181806483,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"\n Background<\/jats:title>\n Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major cause of dementia.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n The aim of this study was to investigate the effect of aerobic training on the expression changes of\n Notch1<\/jats:italic>\n ,\n Rbpjk<\/jats:italic>\n ,\n Hes1<\/jats:italic>\n , and\n Hey1<\/jats:italic>\n genes in the hippocampus of Alzheimer rats.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Forty, 8-week-old male Wistar rats were divided into four groups: control (n\u2009=\u200910), exercise (n\u2009=\u200910), AD (n\u2009=\u200910), AD\u2009+\u2009exercise (n\u2009=\u200910). Endurance training was implemented with increasing intensity starting at 15\u2005m\/min in the first week and progressing to speeds of 16\u201320\u2005m\/min over the next five weeks with increased durations each week. After 6 weeks, animals were euthanized and hippocampus was collected, frozen and RNA was isolated to quantify\n Notch1<\/jats:italic>\n ,\n Rbpjk<\/jats:italic>\n ,\n Hes1<\/jats:italic>\n , and\n Hey1<\/jats:italic>\n expression. All statistical analyses and graphs were conducted using SPSS and visualized using GraphPad Prism, with significance set at p\u2009<\u20090.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One-way analysis of variance with Tukey's post-hoc analysis found that the Alz group had significantly lower expression of\n Notch1<\/jats:italic>\n with increased expression of\n Rbpjk<\/jats:italic>\n and\n Hes1<\/jats:italic>\n . Conversely, the AD\u2009+\u2009Ex group was observed to have significantly higher\n Notch1<\/jats:italic>\n and significantly lower\n Rbpjk<\/jats:italic>\n compared to the AD group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These findings suggest that exercise may serve as a complementary neuroprotective intervention via manipulation of\n Notch1<\/jats:italic>\n signaling. Overall, the study highlights the need for further research on the relationship between physical activity and gene expression in the context of AD.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13872877261434058","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:34:47Z","timestamp":1774442087000},"page":"545-552","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Aerobic exercise significantly alters\n Notch1<\/i>\n signaling in a neurotoxic hippocampal rat model of Alzheimer's disease"],"prefix":"10.1177","volume":"111","author":[{"given":"Yosra","family":"Tavan","sequence":"first","affiliation":[{"name":"University of Mazandaran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayyeh","family":"Roozegar","sequence":"additional","affiliation":[{"name":"University of Mazandaran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziya Fallah","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"University of Mazandaran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abolfazl","family":"Akbari","sequence":"additional","affiliation":[{"name":"University of Mazandaran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadijeh","family":"Nasiri","sequence":"additional","affiliation":[{"name":"University of Mazandaran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mozhgan","family":"Memarmoghaddam","sequence":"additional","affiliation":[{"name":"University of Mazandaran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahid","family":"Talebi","sequence":"additional","affiliation":[{"name":"University of Maragheh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8124-8072","authenticated-orcid":false,"given":"Darpan I.","family":"Patel","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Texas Medical Branch at Galveston"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003394"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.31661\/gmj.v6i3.820"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2012.02.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01828-x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-95228-4_17"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1002-3"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.227561"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1030"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1475"},{"key":"e_1_3_3_12_2","first-page":"79","article-title":"Cognitive health progression associated with physical exercise","volume":"8","author":"Archer T","year":"2018","unstructured":"Archer T. Cognitive health progression associated with physical exercise. Open Access J Neurol Neurosurg 2018; 8: 79\u201380.","journal-title":"Open Access J Neurol Neurosurg"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v16i4.22"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1391611"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-020-00633-z"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062897"},{"key":"e_1_3_3_17_2","first-page":"331","article-title":"Neuroprotective effect of exercise on Alzheimer\u2019s disease in rats: role of nuclear factor erythroid 2-related factor 2 (NRF2)","volume":"41","author":"Aboudeya HM","year":"2021","unstructured":"Aboudeya HM, Michel TN, Attia MM, et al. Neuroprotective effect of exercise on Alzheimer\u2019s disease in rats: role of nuclear factor erythroid 2-related factor 2 (NRF2). Bull Egypt Soc Physiolg Sci 2021; 41: 331\u2013343.","journal-title":"Bull Egypt Soc Physiolg Sci"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02514-7"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144901"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030440"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.01.002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-025-00737-3"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00067-4"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112358"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.995"},{"key":"e_1_3_3_26_2","first-page":"1","article-title":"Notch1 hallmarks fibrillary depositions in sporadic Alzheimer\u2019s disease","volume":"4","author":"Brai E","year":"2016","unstructured":"Brai E, Alina Raio N, Alberi L. Notch1 hallmarks fibrillary depositions in sporadic Alzheimer\u2019s disease. Acta Neuropathol Commun 2016; 4: 1\u201321.","journal-title":"Acta Neuropathol Commun"},{"key":"e_1_3_3_27_2","article-title":"Altered expression of Notch1 in Alzheimer's disease","volume":"14","author":"Cho S-J YS-M","year":"2019","unstructured":"Cho S-J YS-M, Jo C, et al. Altered expression of Notch1 in Alzheimer's disease. PloS One 2019; 14: e0224941.","journal-title":"PloS One"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700442"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2009.11.001"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0391-x"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2021.103657"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2024.07.017"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0291995"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-22179-z"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1590\/1980-5764-dn-2023-0015"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan8821"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759091419892692"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1243869"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03869-9"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt134"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910244"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261434058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261434058","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261434058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T08:51:58Z","timestamp":1779180718000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261434058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/13872877261434058"],"URL":"https:\/\/doi.org\/10.1177\/13872877261434058","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]}}}