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Posterior cortical atrophy (PCA) is a rare form of AD with progressive neurovisual impairment related to degeneration in visual processing areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate how alterations in eye movement metrics, measured through video-oculography (VOG), reflect dysfunction across distinct brain networks in various AD phenotypes, with particular emphasis on PCA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study compared oculomotor parameters derived from VOG saccade analysis in early AD patients exhibiting two clinical phenotypes, PCA-AD (n\u2009=\u200921) and amnestic mild cognitive impairment (aMCI-AD, n\u2009=\u200911), along with 27 age-matched controls. Parameters analyzed included saccade latency, gain, velocity, intrusions and antisaccade error rates. All patients exhibited cerebrospinal fluid biomarkers consistent with AD pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>As expected, neuropsychological testing revealed more severe neurovisual and executive deficits in PCA-AD versus aMCI-AD, and greater memory storage impairment in aMCI. Oculomotor data showed that PCA-AD patients exhibited prolonged saccade latencies, reduced gain, slower vertical saccades, and increased antisaccade errors compared to controls and aMCI-AD. Receiver operating characteristic analysis combining key saccadic metrics demonstrated up to 90% sensitivity and specificity in distinguishing PCA from controls and aMCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings support the use of VOG oculomotor metrics as phenotypic biomarkers in differentiating AD clinical forms. In PCA, they reflect the dysfunction of visuo-spatial attentional networks and their interaction with subcortical eye movement control circuits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261435137","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T08:31:54Z","timestamp":1774513914000},"page":"609-623","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhancing atypical Alzheimer's disease phenotyping through the oculomotor window in posterior cortical atrophy"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5061-5797","authenticated-orcid":false,"given":"Lejla","family":"Koric","sequence":"first","affiliation":[{"name":"Assistance Publique H\u00f4pitaux de Marseille"},{"name":"Aix-Marseille Universit\u00e9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Mourre","sequence":"additional","affiliation":[{"name":"Assistance Publique H\u00f4pitaux de Marseille"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Trompette","sequence":"additional","affiliation":[{"name":"Assistance Publique H\u00f4pitaux de Marseille"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Brillant","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrtille","family":"Favre","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Trinquet","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Ceccaldi","sequence":"additional","affiliation":[{"name":"Assistance Publique H\u00f4pitaux de Marseille"},{"name":"Aix-Marseille Universit\u00e9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Felician","sequence":"additional","affiliation":[{"name":"Assistance Publique H\u00f4pitaux de Marseille"},{"name":"Aix-Marseille Universit\u00e9"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520310107024"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000140290.80962.BF"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.4.388"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00414-3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz136"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000086814.35352.B3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009323"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-024-03126-w"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.11.1061"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.3770"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq287"},{"key":"e_1_3_3_15_2","first-page":"225","article-title":"Posterior cortical atrophy","volume":"26","author":"Delamont RS","year":"1989","unstructured":"Delamont RS, Harrison J, Field M, et al. 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