{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:09:54Z","timestamp":1779181794008,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20204Y0251"],"award-info":[{"award-number":["20204Y0251"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2024QN074"],"award-info":[{"award-number":["2024QN074"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Preclinical studies suggest acupuncture may offer symptomatic relief or modify disease progression in Alzheimer's disease (AD), yet clinical evidence remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated whether adding acupuncture to cholinesterase inhibitors improves outcomes in patients with mild AD and whether any benefits persist after treatment ends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this randomized, single-blind trial, participants with mild AD received either active or sham acupuncture three times per week for 14 weeks in addition to ongoing donepezil therapy, followed by a 14-week washout phase during which acupuncture was discontinued while donepezil was maintained. The primary outcome was change in Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog12) from baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 160 participants were enrolled, and 157 were included in the primary analysis (78 active, 79 sham). At week 14, the mean change in ADAS-cog12 was \u22121.20 for the active acupuncture group versus 0.36 for the sham acupuncture group, yielding a difference of \u22121.50 (p\u2009&lt;\u20090.001). After washout, no significant difference remained (difference, \u22120.31; p\u2009=\u20090.54). Adverse events occurred in 37.2% of the active and 45.6% of the sham group. Donepezil-related adverse events were less frequent with active acupuncture (6.4% versus 16.5%; p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acupuncture, when added to donepezil, improved cognition during active treatment and was associated with fewer cholinergic side effects in patients with mild AD. The cognitive benefits did not persist after acupuncture was discontinued, suggesting that acupuncture serves as an adjunctive symptomatic therapy rather than a disease-modifying intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov [NCT05078944].<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261435880","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T14:02:11Z","timestamp":1774879331000},"page":"757-767","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acupuncture as an adjunct therapy for mild Alzheimer's disease: A randomized clinical trial"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8778-7445","authenticated-orcid":false,"given":"Xiehe","family":"Kong","sequence":"first","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"},{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9282-0222","authenticated-orcid":false,"given":"Rong","family":"Han","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopeng","family":"Fan","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-1117","authenticated-orcid":false,"given":"Kai","family":"Wei","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Traditional Chinese Medicine for Mental Health, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9642-1296","authenticated-orcid":false,"given":"Zhao","family":"Ma","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9739-6106","authenticated-orcid":false,"given":"Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"},{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1589-6351","authenticated-orcid":false,"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"},{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-4047","authenticated-orcid":false,"given":"Yanting","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"},{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"},{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jue","family":"Hong","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"},{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"},{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-8691","authenticated-orcid":false,"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"},{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9532-4870","authenticated-orcid":false,"given":"Xiaopeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Shanghai University of Traditional Chinese Medicine"},{"name":"Shanghai University of Traditional Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"World Alzheimer Report 2024: Global changes in attitudes to dementia","author":"Alzheimer\u2019s Disease International","year":"2024","unstructured":"Alzheimer\u2019s Disease International. 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