{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:10:03Z","timestamp":1779181803286,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K24AG035007"],"award-info":[{"award-number":["K24AG035007"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG036694"],"award-info":[{"award-number":["P01AG036694"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Apathy is a common neuropsychiatric symptom in Alzheimer's disease (AD) and has been linked to greater levels of AD biomarkers (amyloid-\u03b2, tau). However, it is unclear whether early patterns of amyloid deposition may impact development of apathy symptoms in the future.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We sought to examine whether amyloid-\u03b2 levels, both globally and in brain regions associated with motivation, could predict future apathy symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants (n\u2009=\u2009199, mean age\u2009=\u200979.9) were part of the Harvard Aging Brain Study, a longitudinal observational cohort of individuals without cognitive or psychiatric impairment at baseline. All underwent MRI and Pittsburgh Compound B (PiB)-PET for amyloid-\u03b2 at baseline and completed questionnaires of self- and study-partner-rated apathy 7.8\u2009\u00b1\u20091 years later using the Apathy Evaluation Scale. Linear regression models assessed whether regional PiB levels predicted future apathy scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher baseline cortical PiB levels in a frontal, lateral parieto-temporal, and retrosplenial aggregate were associated with greater study-partner-rated apathy, but not self-rated apathy, and no specific regional associations were observed outside of the aggregate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results provide insight into early neurobiological underpinnings of AD-related apathy. Additionally, these data may have clinical implications regarding the risk of developing apathy symptoms in amyloid-\u03b2-positive individuals as cognition declines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261436755","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:42:03Z","timestamp":1775486523000},"page":"851-859","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline cortical amyloid-\u03b2 levels are associated with subsequent study-partner-rated apathy in community-dwelling older adults"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8707-1826","authenticated-orcid":false,"given":"Catherine E.","family":"Munro","sequence":"first","affiliation":[{"name":"Department of Neurology, Brigham and Women's Hospital"},{"name":"Department of Psychiatry, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Beltran","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phebe","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Hanseeuw","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Universit\u00e9 Catholique de Louvain\/Cliniques Universitaires Saint-Luc, Brussels, Belgium"},{"name":"Department of Radiology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorene M.","family":"Rentz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women's Hospital"},{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Properzi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9425-1059","authenticated-orcid":false,"given":"Patrizia","family":"Vannini","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women's Hospital"},{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca E.","family":"Amariglio","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women's Hospital"},{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakeel T.","family":"Quiroz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"},{"name":"Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia"},{"name":"Boston University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Sik","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women's Hospital"},{"name":"Department of Neurology, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Blacker","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital\/Harvard Medical School, Boston, MA, USA"},{"name":"Harvard T. 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