{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:52:42Z","timestamp":1783785162962,"version":"3.55.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Chubei Itoh Foundation"},{"name":"University of Kobe GAP Fund Program"},{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["23K06866"],"award-info":[{"award-number":["23K06866"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100020148","name":"Foundation of Kinoshita Memorial Enterprise","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020148","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021128","name":"Hyogo Science and Technology Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD), the most common neurodegenerative cause of dementia, is defined by amyloid-\u03b2 (A\u03b2) plaques and neurofibrillary tangles of hyperphosphorylated tau, while inflammatory processes are increasingly recognized as contributors to its pathogenesis. However, the clinical relevance of inflammation-related microRNAs (miRNAs) in AD remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate whether inflammation-related miRNAs in plasma and cerebrospinal fluid (CSF) are associated with AD pathology and apolipoprotein E (\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      ) \u03b54 status in individuals with mild cognitive impairment (MCI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We investigated the expression of inflammation-related miR-125b, miR-146a, and miR-155-5p in plasma and CSF of individuals with MCI (N\u2009=\u2009103), stratified by\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 status. Associations with established CSF biomarkers of AD pathology were assessed. In a subset receiving the anti-A\u03b2 antibody lecanemab (N\u2009=\u200918), longitudinal changes in plasma inflammation-related microRNA levels were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma miR-155-5p levels in\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 non-carriers were associated with the CSF A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      ratio, whereas in \u03b54 carriers, CSF miR-155-5p levels correlated with phosphorylated tau 181 and total tau. miR-155-5p was the only inflammation-related miRNA showing consistent\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54-dependent differential expression in both plasma and CSF. In the lecanemab-treated subset, plasma miR-155-5p increased significantly after 6 months and remained elevated at 12 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      miR-155-5p, an inflammation-related miRNA modulated by\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54, is associated with AD-relevant pathological features and may provide complementary information at the MCI stage, with potential utility in monitoring biological responses to anti-A\u03b2 therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261437135","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T09:55:01Z","timestamp":1775210101000},"page":"878-889","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Inflammation-related miR-155-5p as an\n                    <i>APOE<\/i>\n                    \u03b54-modulated biomarker for amyloid pathology in mild cognitive impairment"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8728-5226","authenticated-orcid":false,"given":"Kohsuke","family":"Yoshida","sequence":"first","affiliation":[{"name":"Kobe University Graduate School of Health Sciences"},{"name":"Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nonoka","family":"Saito","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-7852","authenticated-orcid":false,"given":"Ryuichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsaburo","family":"Ando","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0046-4628","authenticated-orcid":false,"given":"Tetsuo","family":"Kashibayashi","sequence":"additional","affiliation":[{"name":"Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fujita","sequence":"additional","affiliation":[{"name":"Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Takano","sequence":"additional","affiliation":[{"name":"Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5300-8589","authenticated-orcid":false,"given":"Hisatomo","family":"Kowa","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hashiramoto","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000313"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0333-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.103911"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858417721150"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90529-Y"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90530-4"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/35002607"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/35040556"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02745-6"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep26697"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.09.011"},{"key":"e_1_3_3_16_2","first-page":"365","article-title":"MicroRNA (miRNA) speciation in Alzheimer\u2019s disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)","volume":"3","author":"Alexandrov PN","year":"2012","unstructured":"Alexandrov PN, Dua P, Hill JM, et al. 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