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Enteric glial cells (EGCs) represent a fundamental cellular constituent that upholds the structural and functional integrity of the MGBA. However, the specific mechanistic role of EGCs in the pathogenesis of AD remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study aimed to investigate the synergistic interaction between gut microbiota (GM) dysbiosis and EGCs activation in a mouse of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Amyloid precursor protein (APP)\/presenilin 1 (PS1) transgenic AD mice were utilized as the experimental model. Behavioral experiments, 16S rRNA sequencing, Nissl staining, and immunofluorescence staining were used to evaluate the related changes of AD in cognitive function, neuropathology, GM, and EGCs, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      AD mice exhibited significant cognitive dysfunction, with obvious neuronal damage and A\u03b2 plaques formation in the hippocampus and primary somatosensory cortex. The GM composition of AD mice was significantly altered,\n                      <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                      -diversity decreased, and the dominant bacterial population was significantly different from the control group. Morphologically, EGCs in the myenteric plexus (MP) and submucosal plexus (SP) of AD mice were markedly activated, concomitant with a reduction in neuronal count. This alteration in EGCs-neuron interactions was shown to be region-specific in MP and SP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study confirms characteristic alterations in GM and abnormal EGCs activation in AD mice, while also uncovering regional specificity of these changes within the enteric nervous system. These findings may provide experimental evidence for the development of targeted intervention strategies for AD based on GM and EGCs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261441247","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:38:29Z","timestamp":1776955109000},"page":"1263-1277","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dysbiosis of gut microbiota synergizes with the activation of enteric glial cells to promote Alzheimer's disease"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-6724","authenticated-orcid":false,"given":"Qian","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Tangdu Hospital, The Fourth Military Medical University, Xi\u2019an, China"},{"name":"Department of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5089-8574","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6813-8905","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi\u2019an, China"},{"name":"Guangxi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha-Sha","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Anatomy and K. K. 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Leung Brain Research Centre, The Fourth Military Medical University, Xi\u2019an, China"},{"name":"Guangxi Medical University"},{"name":"Zunyi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Tangdu Hospital, The Fourth Military Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166841"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04543-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2486518"},{"key":"e_1_3_3_6_2","article-title":"Advances in fecal microbiota transplantation for gut dysbiosis-related diseases","volume":"12","author":"Hou S","year":"2025","unstructured":"Hou S, Yu J, Li Y, et al. 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