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Accumulating evidence suggests that SCD may be a prodromal phase of progressed cognitive decline stages, particularly Alzheimer's disease. The risk factors, mainly comorbidities, associated with SCD are not well known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to examine whether diabetes, cardiovascular disease (CVD), with a focus on stroke and coronary heart disease (CHD), and other comorbidities are associated with SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a quantitative analysis employing weighted analyses on cross-sectional data adopted from the 2022 Behavioral Risk Factor Surveillance System.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results showed that out of 60,492 adults aged 45 years and older, 6423 individuals (10.45%) reported experiencing SCD, 19.49% diabetes, 11.78% CHD, and 5.67% stroke. Among diabetics, 33.41% reported insulin use. Comorbidities that were significantly associated with SCD included stroke (OR: 1.61; 95%CI: 1.24\u20132.08), CHD (OR:1.56; 95% CI: 1.27,1.92), and diabetes (OR: 1.25; 95%CI: 1.02\u20131.55). Other significant comorbidities included depressive disorder (OR: 2.56; 95% CI: 2.18\u20133.02), kidney disease (OR: 1.89; 95% CI: 1.24\u20132.87), arthritis (OR: 1.31; 95%CI: 1.07\u20131.61), and asthma (OR: 1.27; 95%CI: 1.06\u20131.52). Age of diagnosis with diabetes was younger among participants with SCD. Insulin use was significantly associated with SCD, particularly among type 2 diabetes, accounting for duration of diabetes. (OR: 1.39; 95% CI:1.02- 1.92).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given the importance of SCD as a precursor to progressed cognitive impairment, these findings highlight the need for awareness and proactive screening for cognitive dysfunction among high-risk individuals with CVDs, diabetes, depression, and other comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261441275","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:35:19Z","timestamp":1776267319000},"page":"1121-1138","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Subjective cognitive decline among older adults and its link to diabetes, cardiovascular diseases, and other comorbidities: A US population-based study"],"prefix":"10.1177","volume":"111","author":[{"given":"Marwa","family":"Shouman","sequence":"first","affiliation":[{"name":"American University of Beirut"},{"name":"American University of Beirut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayad A.","family":"Jaffa","sequence":"additional","affiliation":[{"name":"American University of Beirut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abla M.","family":"Sibai","sequence":"additional","affiliation":[{"name":"American University of Beirut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Hunt","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0318-7611","authenticated-orcid":false,"given":"Miran A.","family":"Jaffa","sequence":"additional","affiliation":[{"name":"American University of Beirut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"CDC. 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