{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:06:26Z","timestamp":1780391186967,"version":"3.54.1"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["No. 2023YFC3603604"],"award-info":[{"award-number":["No. 2023YFC3603604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["No. 2023YFC3603605"],"award-info":[{"award-number":["No. 2023YFC3603605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science & Technology Department of Jiangsu Province","award":["No. BE2023778"],"award-info":[{"award-number":["No. BE2023778"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Alzheimer's disease (AD) is a multifactorial disorder. The sortilin-related receptor 1 (\n                      <jats:italic toggle=\"yes\">SORL1<\/jats:italic>\n                      ) gene, which regulates the trafficking and recycling of amyloid precursor protein, has been reported to be associated with the development of AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study investigated the impact of\n                      <jats:italic toggle=\"yes\">SORL1<\/jats:italic>\n                      polymorphisms (rs641120 and rs1784933) and their interaction with the apolipoprotein E (\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      ) \u03b54 allele on AD preclinical stages\u2014subjective cognitive decline (SCD) and mild cognitive impairment (MCI). We also explored the association between the rs641120 and serum biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 225 SCD, 131 MCI, and 62 normal controls (NC). Logistic regression models were utilized to assess genetic risks and interactions. Nonparametric tests or t-tests were employed to examine group differences stratified by protective genes in neuropsychological performance and biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The rs641120 A allele was associated with a lower risk of SCD and MCI, within AA genotype (OR\u2009=\u20090.575) and AG genotype (OR\u2009=\u20090.588). In MCI patients, the A allele was associated with lower levels of serum A\u03b2\n                      <jats:sub>1\u221242<\/jats:sub>\n                      and p-tau181. An interaction between\n                      <jats:italic toggle=\"yes\">SORL1<\/jats:italic>\n                      rs1784933 and the\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 allele was identified. In NC carrying \u03b54, AA is associated with higher risk of SCD (OR\u2009=\u200912.030,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.029) and MCI (OR\u2009=\u200910.015,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.044). In SCD patients without \u03b54, AA genotype is associated with lower risk of MCI (OR\u2009=\u20090.301,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">SORL1<\/jats:italic>\n                      polymorphisms influence SCD and MCI susceptibility and correlate with AD serum biomarkers. Additionally, we detected an interaction between\n                      <jats:italic toggle=\"yes\">SORL1<\/jats:italic>\n                      rs1784933 and the\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 genotype.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261441644","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:54:43Z","timestamp":1776434083000},"page":"1180-1191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of\n                    <i>SORL1<\/i>\n                    polymorphisms and\n                    <i>SORL1-APOE<\/i>\n                    \u03b54 interaction with risk of subjective cognitive decline and mild cognitive impairment in the Chinese population"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9764-7849","authenticated-orcid":false,"given":"Fanfan","family":"Meng","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2251-4205","authenticated-orcid":false,"given":"Tingting","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4856-3347","authenticated-orcid":false,"given":"Xi","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1470-8984","authenticated-orcid":false,"given":"Hanbo","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9728-7302","authenticated-orcid":false,"given":"Jiaping","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyun","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0557-026X","authenticated-orcid":false,"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-4397","authenticated-orcid":false,"given":"Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2647-9729","authenticated-orcid":false,"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical 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