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All methods are illustrated with hypothetical examples, and ready-to-use SAS code is provided in the Supplemental Material.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The proposed models successfully handle complex longitudinal data structures typical trials with OLE phases, offering greater statistical efficiency and more comprehensive capture of treatment effects over extended periods compared with traditional approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These flexible, efficient statistical models are well-suited for rare disease and long-duration AD trials. Wider adoption and further validation of these approaches may enhance the power and interpretability of future neurodegenerative disease trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261441645","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:45:06Z","timestamp":1776087906000},"page":"1192-1199","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Statistical models for Alzheimer's disease clinical trials: Lessons learned from the DIAN-TU Platform Trial"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-6694","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6808-8737","authenticated-orcid":false,"given":"Guoqiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"},{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0044-4499","authenticated-orcid":false,"given":"Chengjie","family":"Xiong","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-6599","authenticated-orcid":false,"given":"Guogen","family":"Shan","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Cao","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Llibre-Guerra","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hassenstab","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"McDade","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Bateman","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.07.005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01369-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.057320"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(25)00024-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7811"},{"key":"e_1_3_3_7_2","article-title":"Proportional constrained longitudinal data analysis models for clinical trials in sporadic Alzheimer\u2019s disease","volume":"8","author":"Wang G","year":"2022","unstructured":"Wang G, Liu L, Li Y, et al. 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