{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:05:35Z","timestamp":1780391135211,"version":"3.54.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 111-2314-B-182A-036-MY2,"],"award-info":[{"award-number":["MOST 111-2314-B-182A-036-MY2,"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112-2628-B-182-007-MY3,"],"award-info":[{"award-number":["NSTC 112-2628-B-182-007-MY3,"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114-2314-B-182A-061-MY3"],"award-info":[{"award-number":["NSTC 114-2314-B-182A-061-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chang Gung Memorial Hospital Research Fund","award":["CORPG3P0281,"],"award-info":[{"award-number":["CORPG3P0281,"]}]},{"name":"Chang Gung Memorial Hospital Research Fund","award":["CORPG3P0291"],"award-info":[{"award-number":["CORPG3P0291"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tau pathology is the primary biological predictor of cognitive decline in Alzheimer's disease (AD). However, the high cost and limited availability of tau positron emission tomography (PET), particularly in Asian clinical settings, necessitate practical surrogate indicators of tau burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine if cognitive performance\u2014specifically the Alzheimer's Disease Assessment Scale\u2013Cognitive Subscale (ADAS-Cog11)\u2014can serve as an accessible surrogate for global tau PET burden in amyloid-positive individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this cross-sectional study of 182 participants (65 amyloid-positive) underwent\n                      <jats:sup>18<\/jats:sup>\n                      F-florbetapir amyloid PET,\n                      <jats:sup>18<\/jats:sup>\n                      F-florzolotau tau PET, magnetic resonance imaging (MRI), and standardized neuropsychological testing. Global tau standardized uptake value ratios (SUVr) were categorized into low, intermediate, and high using a data-driven AD-vulnerable meta-volume of interest. Associations among cognition, amyloid Centiloid (CL) values, and tau burden were examined. ROC analyses identified cognitive thresholds discriminating elevated tau burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tau SUVr increased progressively with diagnostic severity, whereas amyloid CL values did not associate with cognitive scores within amyloid-positive or amyloid-negative subgroups. In contrast, ADAS-Cog11 (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.46) and Free and Cued Selective Reminding Test delayed recall (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.20) were significantly associated with global tau SUVr (all p\u2009&lt;\u20090.05). ADAS-Cog11\u2009&gt;\u200925 discriminated elevated tau burden with good diagnostic performance (AUC = 0.85; sensitivity 61.5%; specificity 90%). Amyloid CL values did not significantly distinguish high tau burden (p\u2009=\u20090.24).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ADAS-Cog11 provides an accessible complementary indicator of global tau burden independent of amyloid deposition. An ADAS-Cog11 cutoff &gt;25 may aid clinical stratification for anti-amyloid therapies in settings where tau PET is unavailable, supporting scalable and accessible precision assessment in AD care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261441801","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:49:32Z","timestamp":1776433772000},"page":"1212-1223","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["ADAS-Cog11 performance as a surrogate of tau PET burden in an Asian Alzheimer's disease cohort"],"prefix":"10.1177","volume":"111","author":[{"given":"Yu-Jyun","family":"Hong","sequence":"first","affiliation":[{"name":"New Taipei Municipal TuCheng Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Radiological 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Center, Chang Gung University, Taoyuan, Taiwan"},{"name":"Department of Nuclear Medicine and Center for Advanced Molecular Imaging and Translation, Linkou Chang Gung Memorial Hospital, \rTaoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Lun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Linkou Chang Gung Memorial Hospital, Taiwan School of Medicine, Chang Gung University, \rTaoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Linkou Chang Gung Memorial Hospital, Taiwan School of Medicine, Chang Gung University, \rTaoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6422-8870","authenticated-orcid":false,"given":"Jung Lung","family":"Hsu","sequence":"additional","affiliation":[{"name":"New Taipei Municipal TuCheng 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