{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:04:23Z","timestamp":1780391063858,"version":"3.54.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Korea Health Technology R&D Project","award":["HI22C0667"],"award-info":[{"award-number":["HI22C0667"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Amyloid PET\u2013positive mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease (AD), but its longitudinal clinical and biomarker trajectories vary considerably. Evidence linking oral interventions to amyloid-related biomarkers in this population remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare 18-month clinical outcomes and longitudinal changes in plasma amyloid-\u03b2 (A\u03b2) oligomerization tendency and amyloid PET burden according to Ginkgo biloba use in amyloid PET\u2013positive MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included 35 amyloid PET\u2013positive MCI patients who underwent baseline and 18-month clinical evaluations, serial plasma A\u03b2 oligomerization measurements using the Multimer Detection System\u2013Oligomerized A\u03b2 (MDS-OA\u03b2) assay, and paired baseline and 18-month\n                      <jats:sup>18<\/jats:sup>\n                      F-FC119S amyloid PET. Patients received Ginkgo biloba extract 240\u2005mg\/day (n\u2009=\u200921) or Non-Ginkgo cognitive enhancers (n\u2009=\u200914). Clinical stability, conversion to AD dementia (Korean Instrumental Activities of Daily Living \u22650.40), changes in MDS-OA\u03b2, and changes in global cortical standardized uptake value ratio (SUVR) were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline characteristics were comparable between groups. At 18 months, all Ginkgo-treated patients remained clinically stable, whereas 57.1% of Non-Ginkgo patients showed cognitive decline. Conversion to AD dementia occurred in none of the Ginkgo group and in 28.6% of the Non-Ginkgo group. Plasma MDS-OA\u03b2 decreased with Ginkgo but increased without Ginkgo. Global amyloid PET SUVR remained stable in the Ginkgo group and increased in the Non-Ginkgo group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In amyloid PET\u2013positive MCI, Ginkgo biloba use was associated with sustained clinical stability, reduced plasma A\u03b2 oligomerization tendency, and attenuation of amyloid PET progression over 18 months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261441816","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:41:54Z","timestamp":1776267714000},"page":"1224-1233","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Ginkgo biloba and longitudinal changes in amyloid PET and plasma amyloid-\u03b2 oligomerization in amyloid-positive mild cognitive impairment: A retrospective analysis"],"prefix":"10.1177","volume":"111","author":[{"given":"YoungSoon","family":"Yang","sequence":"first","affiliation":[{"name":"Soonchunhyang University Cheonan Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4195-8971","authenticated-orcid":false,"given":"Yong Tae","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hyoja Geriatric Hospital, Yongin-si, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cb3e25"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01329-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph14040305"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-3080-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11010107"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13060651"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.683"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70206-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1913"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3736\/jcim20120605"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4103"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.11.1409"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003120.pub2"},{"key":"e_1_3_3_16_2","first-page":"508","article-title":"Ginkgo biloba for prevention of dementia: a systematic review and meta-analysis","volume":"98","author":"Charernboon T","year":"2015","unstructured":"Charernboon T, Jaisin K. 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