{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:06:50Z","timestamp":1780391210647,"version":"3.54.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008503","name":"CIMIT","doi-asserted-by":"crossref","award":["PA-7723164916"],"award-info":[{"award-number":["PA-7723164916"]}],"id":[{"id":"10.13039\/100008503","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cognitive testing is critical for screening, diagnosing, and monitoring neurocognitive disorders, but current tests are limited by long administration times and the need for trained personnel. Digital cognitive testing offers a convenient and highly repeatable alternative to track cognitive decline, which is essential for evaluating patient care and in clinical trials. To address these limitations, we developed a novel digital spatial working memory test called the D-Cog.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess the feasibility, validity, and diagnostic utility of the D-Cog in a clinical population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with Alzheimer's disease (AD), Lewy body dementia (DLB), Parkinson's disease (PD), and cognitively normal controls (CN) were included. During clinical visits, a medical assistant administered the D-Cog test, presented as a \u201cserious game\u201d on an iPad.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The D-Cog showed high participant engagement, although engagement decreased with advancing cognitive impairment. A significant difference in the mean D-Cog score was observed between CN and both AD and DLB\/PD groups (p\u2009&lt;\u20090.003). Additionally, a significant correlation between the D-Cog score and the Mini-Mental State Examination was identified (r\u2009=\u20090.65, p\u2009&lt;\u20090.001, 95% CI: 0.52\u20130.75). The D-Cog demonstrated good discrimination between groups, with AUCs of 0.96 (95% CI: 0.91\u20131.00) for AD versus healthy controls and 0.88 (95% CI: 0.75\u20130.97) for MCI versus healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The D-Cog is a feasible and valid digital cognitive test with potential clinical utility across neurocognitive disorders. Although engagement was lower in advanced dementia, these findings support further development and exploration of the D-Cog, particularly for potential in-home assessments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261442078","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:04:38Z","timestamp":1776780278000},"page":"1309-1316","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and validity of the D-Cog: A novel digital spatial working memory test for dementia assessment"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6442-2910","authenticated-orcid":false,"given":"Christian Sand\u00f8e","family":"Musaeus","sequence":"first","affiliation":[{"name":"Danish Dementia Research Centre (DDRC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte B.","family":"Curnin","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva","family":"Muthupalaniappan","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1786-744X","authenticated-orcid":false,"given":"Garrett","family":"Friedman","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Aslarus","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Hayashi","sequence":"additional","affiliation":[{"name":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA"},{"name":"Graduate School of Education, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice A.","family":"Smith","sequence":"additional","affiliation":[{"name":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Z.","family":"Press","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.2152"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215564"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51096"},{"key":"e_1_3_3_7_2","article-title":"Unsupervised mobile cognitive testing for use in preclinical Alzheimer\u2019s disease","volume":"13","author":"Papp KV","year":"2021","unstructured":"Papp KV, Samaroo A, Chou H-C, et al. 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