{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:34:14Z","timestamp":1788024854749,"version":"build-2784847793"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG52583"],"award-info":[{"award-number":["R01AG52583"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The cognitive response to dietary interventions may differ according to levels of Alzheimer's disease\u2013related plasma biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Using data from the MIND clinical trial, we examined whether baseline biomarkers, including A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      , the A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      ratio, and p-tau181, modified the association between the MIND diet and longitudinal change in global cognition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The MIND randomized clinical trial enrolled 604 community-dwelling adults aged 65\u201384 years without cognitive impairment at baseline. Recruitment occurred from January 2017 to April 2018, with data collection continuing through June 2021. Participants were randomized in a 1:1 ratio to the MIND or control diet for 3 years, with counseling on diet adherence and weight loss support provided at the same frequency throughout the intervention. Annual change from baseline in a global cognitive composite z-score was derived from a 12-test battery, with higher scores indicating better cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 602 individuals included in the analysis, 391 (65%) were female, and the mean baseline age was 70.4 (SD\u2009=\u20094.2) years. Baseline levels of A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      and p-tau181 modified the association between MIND assignment and longitudinal change in global cognition, with significant between-group differences in biomarker-related annual cognitive slopes for A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      (\u03b2=0.027, 95%CI 0.006\u20130.048) and p-tau181 (\u03b2=0.023, 95%CI 0.002\u20130.043), but not for the A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The association between the MIND diet intervention and cognition varied by baseline levels of A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      and p-tau181, with greater improvement in cognitive scores in the MIND group than in the control group among individuals with higher biomarker levels.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov Identifier: NCT02817074\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261442856","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T13:46:06Z","timestamp":1777124766000},"page":"1301-1308","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dietary intervention and cognition across Alzheimer's disease biomarker levels: The MIND clinical trial"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6397-7009","authenticated-orcid":false,"given":"Klodian","family":"Dhana","sequence":"first","affiliation":[{"name":"Rush University Medical Center"},{"name":"Rush University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelum T.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Rush University Medical Center"},{"name":"Rush University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Arfanakis","sequence":"additional","affiliation":[{"name":"Rush University Medical Center"},{"name":"Rush University Medical Center"},{"name":"Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Sacks","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Rush University Medical Center"},{"name":"Rush University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ca.980080612"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000271090.28148.24"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13081"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12362"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4668"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.13855"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13187-020-01741-1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25456"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60461-5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009816"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.12923"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.04.011"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207176"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210107"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2006-9409"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004815"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.12.015"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515003451"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2302368"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2021.106270"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617721001089"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.9.1159"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/00207459109150691"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617712001282"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182872ded"},{"key":"e_1_3_3_29_2","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2024","unstructured":"R Core Team. 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