{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:00:32Z","timestamp":1790773232408,"version":"4.1.0"},"reference-count":113,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accelerated long-term forgetting (ALF), the disproportionate loss of information over days or weeks despite normal performance at standard delays, has been proposed as an early cognitive marker of Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Provide a qualitative and quantitative synthesis of current evidence on ALF across the AD continuum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic review and meta-analysis following the PRISMA 2020 guidelines. Eligible studies evaluated episodic memory with delays of at least 1\u2005h in participants across the AD continuum compared to healthy controls. Risk of bias was assessed using the Joanna Briggs Institute (JBI) tools, and pooled effect sizes (Hedges\u2019 g) were calculated for delays of 1 day, 1 week, and 1 month or longer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-eight studies (n\u2009=\u20091399) were included; 16 entered quantitative analyses. The 1-day effect was nonsignificant (g\u2009=\u20090.55, 95% CI \u22120.03\u20131.12). At 1 week, ALF effect was robust (g\u2009=\u20090.63, 95% CI 0.40\u20130.87; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%) and evident in at-risk groups (g\u2009=\u20090.61, 95% CI 0.37\u20130.86) despite intact early retention. Both verbal (g\u2009=\u20090.74) and non-verbal (g\u2009=\u20090.53) tasks, as well as recall (g\u2009=\u20090.61) and recognition (g\u2009=\u20090.70), showed similar sensitivity. Effects persisted at \u22651 month but weakened in at-risk groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ALF is strongly detected in the preclinical stage of AD, especially at a 1-week delay across different materials and retrieval methods. Long-delay memory tests may enhance the sensitivity of neuropsychological assessments for detecting early cognitive issues in the early stages of the AD continuum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261443537","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:24:16Z","timestamp":1776954256000},"page":"1459-1482","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Accelerated long-term forgetting in Alzheimer's disease continuum: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3504-0883","authenticated-orcid":false,"given":"Luca","family":"Pizzoni","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Rome \u201cSapienza\u201d, Rome, Italy"},{"name":"Centre for Cognitive Disorders and Dementia (CDCD), ASL Roma 3, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8694-4645","authenticated-orcid":false,"given":"Andrea Di","family":"Piero","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6316-7145","authenticated-orcid":false,"given":"Barbara","family":"Blasutto","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Casagrande","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Rome \u201cSapienza\u201d, Rome, Italy"},{"name":"Department of Dynamic and Clinical Psychology and Health, University of Rome \u201cSapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1322-5538","authenticated-orcid":false,"given":"Laura","family":"Piccardi","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Rome \u201cSapienza\u201d, Rome, Italy"},{"name":"IRCCS San Raffaele Cassino, Cassino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Guariglia","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Rome \u201cSapienza\u201d, Rome, Italy"},{"name":"Cognitive and Motor Rehabilitation and Neuroimaging Unit, IRCCS Fondazione Santa Lucia, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12068"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00066-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.007"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2021.23"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.3770"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_3_11_2","article-title":"The Alzheimer's Association clinical practice guideline for the diagnostic evaluation, testing, counseling, and disclosure of suspected Alzheimer's disease and related disorders (DETeCD-ADRD): validated clinical assessment instruments","volume":"21","author":"Atri A","year":"2025","unstructured":"Atri A, Dickerson BC, Clevenger C, et al. The Alzheimer's Association clinical practice guideline for the diagnostic evaluation, testing, counseling, and disclosure of suspected Alzheimer's disease and related disorders (DETeCD-ADRD): validated clinical assessment instruments. Alzheimers Dement 2025; 21: e14335.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13123442"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14363"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.02.001"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2018.12.009"},{"key":"e_1_3_3_16_2","volume-title":"Neuropsychological assessment","author":"Lezak MD","year":"2012","unstructured":"Lezak MD, Howieson DB, Bigler ED, et al. Neuropsychological assessment. 5th ed. London: Oxford University Press, 2012.","edition":"5"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.5.1.3"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(13)80253-5"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.1996.8.5.416"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/brcg.1997.0927"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/brcg.1997.0928"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(01)00192-0"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70855-4"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-964997"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0857"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.04.119"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2017.12.012"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10120945"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2018.04.002"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617721000527"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12359-4"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4872"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/02699052.2024.2311349"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2024.2449564"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161173"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30434-9"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30078-4"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00695-2"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51245"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00845-0"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-240067"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae316"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaf478"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0850-6"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1080\/13825585.2020.1842849"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5539"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-240218"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/13825585.2024.2317924"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-025-01833-4"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.12.008"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000091"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000013"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2016.1147530"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnp.12114"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2022.2135441"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(85)90064-8"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.55.1.101"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2626(88)90019-X"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(13)80363-2"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2001000200003"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2020.107351"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104815"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000827"},{"key":"e_1_3_3_64_2","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Br Med J 2021; 372: n71.","journal-title":"Br Med J"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30368-0"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12674"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.02.002"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032816-045136"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.11124\/JBIES-22-00125"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-020-00238-8"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-025-03485-3"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015987"},{"key":"e_1_3_3_77_2","volume-title":"Residuals and Influence in Regression","author":"Cook RD","year":"1982","unstructured":"Cook RD, Weisberg S. Residuals and Influence in Regression. New York: Chapman and Hall, 1982."},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00693-4"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/275317a0"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000120548.24298.DB"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900016151"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci7090111"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.03.005"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220805"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01380.x"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.12.1985"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01326.x"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2025-336750"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.05.006"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(95)80023-9"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/23270"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2018.04.005"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90204-8"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21753"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24983"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00628"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2023.110757"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2024.1448791"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3338"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2177-05.2005"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01150-x"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.3389\/frdem.2023.1161875"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(97)80010-4"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617711000683"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2005.00421.x"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92338-8"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.048"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2025.106461"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2013.04.017"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.02.009"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2024.109931"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261443537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261443537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261443537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:29:34Z","timestamp":1790771374000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261443537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":113,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/13872877261443537"],"URL":"https:\/\/doi.org\/10.1177\/13872877261443537","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]}}}