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Studies in AD rodent models report that KD and\/or ketogenic supplements attenuate cognitive-behavioral impairments, neuroinflammation, amyloid-\u03b2 (A\u03b2) plaques, and tau pathology. However, it is unknown whether KD can similarly benefit individuals with cerebral amyloid angiopathy (CAA), a prevalent condition in which A\u03b2 accumulates in cerebral vessels. CAA is highly comorbid with AD and, on its own, increases the risk of stroke, cognitive impairment, and dementia, yet no effective treatments currently exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether KD can improve cognitive-behavioral and neuropathological outcomes in a mouse model with CAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male Tg-SwDI mice were fed either a standard chow or KD from 3.5 to 7.5 months of age. Following \u223c3 months of dietary intervention, glucose and ketone body levels were assessed, then mice underwent a battery of behavioral tests to evaluate locomotor activity, anxiety-related behaviors, and cognition. Immunohistochemistry was performed to assess amyloid pathology, vascular density, neuroinflammation, white matter integrity, and hippocampal neurogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In addition to KD inducing nutritional ketosis and achieving metabolic benefits, mice on KD exhibited increased activity, enhanced spatial learning and memory, and a trend toward improved spatial working memory. These cognitive benefits were accompanied by an attenuation of amyloid pathology and increased hippocampal neurogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that a KD may be safe and effective in AD and dementia patients with CAA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261445916","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:09:33Z","timestamp":1777907373000},"page":"1563-1586","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ketogenic diet enhances cognitive-behavioral function and hippocampal neurogenesis while attenuating amyloid pathology in Tg-SwDI mice"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3342-0418","authenticated-orcid":false,"given":"Victoria E.","family":"Pulido-Correa","sequence":"first","affiliation":[{"name":"Nova Southeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana V.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Nova Southeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5724-1956","authenticated-orcid":false,"given":"Eleanor J.","family":"Wind","sequence":"additional","affiliation":[{"name":"Nova Southeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YingYing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Nova Southeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chana","family":"Vogel","sequence":"additional","affiliation":[{"name":"Nova Southeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaina","family":"Binu","sequence":"additional","affiliation":[{"name":"Nova Southeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikayla","family":"Jeneske","sequence":"additional","affiliation":[{"name":"Nova Southeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Kuni","sequence":"additional","affiliation":[{"name":"Nova Southeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedika","family":"Chiduruppa","sequence":"additional","affiliation":[{"name":"Nova Southeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Echeverria","sequence":"additional","affiliation":[{"name":"Nova Southeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Nova Southeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5110-9183","authenticated-orcid":false,"given":"Lisa S.","family":"Robison","sequence":"additional","affiliation":[{"name":"Nova Southeastern University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22112"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.17.1.17"},{"key":"e_1_3_3_4_2","article-title":"Cerebral amyloid angiopathy distribution in older people: a cautionary note","volume":"7","author":"Alakbarzade V","year":"2021","unstructured":"Alakbarzade V, French JM, Howlett DR, et al. 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