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Despite global efforts to promote resilience, delay cognitive decline, and slow aging,\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    \u03b52, one of the most robust resilience-associated variants, remains relatively underexplored in translational research. Exceptional longevity offers a window into cognitive trajectories. We present clinical, cognitive and neuroimaging data from five\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    \u03b52\/\u03b53 siblings aged 94\u2013105. Cognition ranged from normal to mild dementia. MRI showed less atrophy than expected for advanced age, and FDG-PET revealed preserved metabolism. Findings demonstrate\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    \u03b52-associated resilience in the oldest-old and offer insight into mechanisms of exceptional cognitive aging with potential translational relevance.\n                  <\/jats:p>","DOI":"10.1177\/13872877261449392","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:34:52Z","timestamp":1780637692000},"page":"104-111","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Longevity and cognitive resilience in a Colombian family carrying the\n                    <i>APOE<\/i>\n                    \u03b52 variant"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3952-1412","authenticated-orcid":false,"given":"Alejandro","family":"Guerrero","sequence":"first","affiliation":[{"name":"Universidad de 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