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For example, a longitudinal study by McCarron et al. (2017) found that 97% of a cohort of 77 DS patients aged 35 years and older developed dementia. Despite this high risk, administrative data on dementia prevalence in this population remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study examines whether the diagnosed prevalence is lower than expected based on epidemiological data and explores differences compared to the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comparative analysis of administrative dementia prevalence (2010\u20132019) was conducted using claims data for adults with and without DS. Prevalence rates were calculated by age and sex. Chi-square tests were applied to assess significance (p\u2009&lt;\u20090.05), with Cram\u00e9r's V and Phi as measures of association. Odds ratios were calculated to evaluate group differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total administrative dementia prevalence was significantly higher in adults with DS (Mean Value (MV) 9.2%\u2009\u00b1\u20091.7% (Standard Deviation (SD))) than those without DS (MV 3.2%\u2009\u00b1\u20090.3% (SD)). Age- and sex-specific analyses also revealed notable differences. For example, in the 56\u201360 years age group, prevalence was MV 28.7%\u2009\u00b1\u20094.6% (SD) in adults with DS versus MV 0.7%\u2009\u00b1\u20090.1% (SD) in those without DS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although administrative dementia prevalence is higher among adults with DS than those without DS, observed rates appear lower than expected based on existing epidemiological data. This suggests a potential underdiagnosis of dementia in the DS population in Germany.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261449417","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:12:43Z","timestamp":1778854363000},"page":"161-174","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["(Alzheimer's) dementia in adults with Down syndrome in Germany: Administrative prevalence based on a claims data analysis"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7947-5290","authenticated-orcid":false,"given":"Milena","family":"Weitzel","sequence":"first","affiliation":[{"name":"University of Duisburg-Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Walendzik","sequence":"additional","affiliation":[{"name":"Essen Research Institute for Medical Management, EsFoMed GmbH, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-1927","authenticated-orcid":false,"given":"Godwin D.","family":"Giebel","sequence":"additional","affiliation":[{"name":"University of Duisburg-Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Raszke","sequence":"additional","affiliation":[{"name":"University of Duisburg-Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Wasem","sequence":"additional","affiliation":[{"name":"University of Duisburg-Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-4306","authenticated-orcid":false,"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"LMU Munich"},{"name":"German Centre for Neurodegenerative Diseases, Site Munich, Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"N\u00fcbling","sequence":"additional","affiliation":[{"name":"LMU Munich"},{"name":"German Centre for Neurodegenerative Diseases, Site Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Wagemann","sequence":"additional","affiliation":[{"name":"LMU Munich"},{"name":"German Centre for Neurodegenerative Diseases, Site Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Wlasich","sequence":"additional","affiliation":[{"name":"LMU Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Pantel","sequence":"additional","affiliation":[{"name":"Institute for General Practice, Goethe University, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina A.","family":"Tesky","sequence":"additional","affiliation":[{"name":"Institute for General Practice, Goethe University, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Schall","sequence":"additional","affiliation":[{"name":"Institute for General Practice, Goethe University, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5955-4142","authenticated-orcid":false,"given":"Thomas","family":"Ruhnke","sequence":"additional","affiliation":[{"name":"AOK Research Institut (WIdO), Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Dr\u00f6ge","sequence":"additional","affiliation":[{"name":"AOK Research Institut (WIdO), Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7628-5707","authenticated-orcid":false,"given":"Theresa","family":"H\u00fcer","sequence":"additional","affiliation":[{"name":"University of Duisburg-Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-020-00748-y"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08092-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.3616"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0123"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0132-6"},{"key":"e_1_3_3_7_2","first-page":"353","article-title":"Alzheimer's disease in Down syndrome","volume":"1","author":"Head E","year":"2012","unstructured":"Head E, Powell D, Gold BT, et al. 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