{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:45:25Z","timestamp":1782812725313,"version":"3.54.5"},"reference-count":49,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P41EB015922"],"award-info":[{"award-number":["P41EB015922"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG054073"],"award-info":[{"award-number":["R01AG054073"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG058533"],"award-info":[{"award-number":["R01AG058533"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG070862"],"award-info":[{"award-number":["R01AG070862"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19AG078109"],"award-info":[{"award-number":["U19AG078109"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Physical functioning (PF) tests are scalable screening tools for neurodegenerative risk that differ by race and ethnicity, reflecting upstream social inequities. Prior work shows that PF relates to Alzheimer's disease blood biomarkers differentially by race and ethnicity, yet it is unclear if similar associations exist with structural brain outcomes (hyperintensities and brain volumes).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated associations between PF and white matter hyperintensity volume (WMH), total brain volume (TBV), and hippocampal volume (HV) and assessed heterogeneity by race and ethnicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cognitively normal non-Hispanic Black (n\u2009=\u2009420), non-Hispanic white (n\u2009=\u2009917), and Hispanic (n\u2009=\u2009828) older adults (mean [SD] age\u2009=\u200964.7 [8.4]) from the Healthy Aging Brain Study-Health Disparities cohort completed the Timed Up and Go (TUG) and Short Physical Performance Battery (SPPB). Brain imaging was collected via 3\u2005T magnetic resonance imaging (MRI). Multivariable linear models related PF to brain imaging outcomes (normalized by intracranial volume) and assessed heterogeneity by race and ethnicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bonferroni adjusted significant (p\u2009&lt;\u20090.05) associations were observed between WMH and PF (TUG: \u03b2\u2009=\u20090.28, 95% CI\u2009=\u20090.17, 0.40; SPPB:\u03b2\u2009=\u2009\u22120.19, 95% CI\u2009=\u2009\u22120.32, \u22120.07), TBV and PF (TUG: \u03b2\u2009=\u2009\u22120.50, 95% CI\u2009=\u2009\u22120.61, \u22120.40; SPPB: \u03b2\u2009=\u20090.30, 95% CI\u2009=\u20090.18, 0.42), and HV and PF (TUG: \u03b2\u2009=\u2009\u22120.28, 95% CI\u2009=\u2009\u22120.38, \u22120.18). Associations were generally similar across race and ethnicity groups for TBV and HV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Poorer PF was associated with reduced TBV and HV and greater WMH. Results support PF tests as scalable, non-invasive indicators of brain health in community-based populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261449514","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:23:58Z","timestamp":1780046638000},"page":"198-209","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of physical functioning as a marker of brain imaging outcomes in a multiethnic community-based cohort"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5067-544X","authenticated-orcid":false,"given":"Gregory","family":"Knell","sequence":"first","affiliation":[{"name":"University of North Texas Health Science Center, Fort Worth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin L.","family":"Meeker","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center, Fort Worth"},{"name":"University of North Texas Health Science Center, Fort Worth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-418X","authenticated-orcid":false,"given":"Zhengyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center, Fort Worth"},{"name":"University of North Texas Health Science Center, Fort Worth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa E.","family":"Petersen","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center, Fort Worth"},{"name":"University of North Texas Health Science Center, Fort Worth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Hall","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center, Fort Worth"},{"name":"University of North Texas Health Science Center, Fort Worth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sid E.","family":"O'Bryant","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center, Fort Worth"},{"name":"University of North Texas Health Science Center, Fort Worth"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.01.018"},{"key":"e_1_3_3_3_2","volume-title":"The next four decades: The older population in the United States: 2010 to 2050","author":"Vincent GK","year":"2010","unstructured":"Vincent GK. The next four decades: The older population in the United States: 2010 to 2050. Washington, DC: US Department of Commerce, Economics and Statistics Administration, 2010."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101580"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2015.06.017"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-153-3-201008030-00258"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2016.06.003"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.112732"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-050212-185535"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090349"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01858-9"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00391-w"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.M85"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2019.1682066"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04120.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2019.103941"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185641"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12734"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14322"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glac169"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdtm.2016.11.008"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.105346"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70252-2"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000049146"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00933-1"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1397"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006075"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880070620"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000110315.26026.EF"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.5755"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.10"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.667"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2482070938"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24647"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.01.002"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw012"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00155"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2023.03.008"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-102"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12894"},{"key":"e_1_3_3_41_2","article-title":"Health and Aging Brain Study-Health Disparities (HABS-HD) methods and partner characteristics","volume":"11","author":"Petersen ME","year":"2025","unstructured":"Petersen ME, Zhou Z, Hall JR, et al. Health and Aging Brain Study-Health Disparities (HABS-HD) methods and partner characteristics. Alzheimers Dement (N Y) 2025; 11: e70140.","journal-title":"Alzheimers Dement (N Y)"},{"key":"e_1_3_3_42_2","article-title":"Diabetes and cortical thickness in ethnically diverse cognitively normal older adults","volume":"17","author":"Tsiknia AA","year":"2025","unstructured":"Tsiknia AA, Tennant VR, Lee N, et al. Diabetes and cortical thickness in ethnically diverse cognitively normal older adults. Alzheimers Dement (Amst) 2025; 17: e70088.","journal-title":"Alzheimers Dement (Amst)"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2014.11.011"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/80.9.896"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S94377"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0763-7"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2006.106047"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/59.1.S34"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2010.199455"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111152298"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261449514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261449514","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261449514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:13:21Z","timestamp":1782810801000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261449514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/13872877261449514"],"URL":"https:\/\/doi.org\/10.1177\/13872877261449514","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]}}}