{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:45:32Z","timestamp":1782812732420,"version":"3.54.5"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Science and Technology Innovation 2030 Major Projects","award":["2022ZD0211600"],"award-info":[{"award-number":["2022ZD0211600"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201587"],"award-info":[{"award-number":["82201587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Taishan Young Scholarship","award":["NO.tsqn202408399"],"award-info":[{"award-number":["NO.tsqn202408399"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>YWHAG has been recognized as a promising biomarker for Alzheimer's disease (AD). However, the precise role of YWHAG within the revised 2024 diagnostic framework for AD remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our study aimed to evaluate YWHAG with established biomarkers to delinea te the role of YWHAG and determine whether it could serve as a complementary biomarker within the 2024 diagnostic criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared YWHAG with established biomarkers among 708 participants from Alzheimer's Disease Neuroimaging Initiative (ADNI) across three domains: 1) diagnostic utility, 2) cross-sectional associations with clinical variables and brain structure, and 3) predictive value for clinical progression risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results demonstrated the accuracy of YWHAG (AUC\u2009=\u20090.856) was comparable to that of FDG-PET (AUC\u2009=\u20090.912) and HVA (AUC\u2009=\u20090.879), but superior to that of T-tau (AUC\u2009=\u20090.796), NFL (AUC\u2009=\u20090.712), and GFAP (AUC\u2009=\u20090.617) in distinguishing AD versus controls. Moreover, YWHAG was consistently among the top three biomarkers most strongly associated with cognitive decline and brain atrophy, alongside HVA and FDG-PET. Furthermore, the YWHAG positive (Y+) group had a significantly higher risk of AD progression (HR\u2009=\u20092.45, 95% CI: 1.75\u20133.43) compared to the YWHAG negative (Y-) group (p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identify YWHAG as a novel biomarker predictive of cognitive decline, brain atrophy, and AD progression. The performances of YWHAG are comparable to established biomarkers such as FDG-PET, HVA and T-tau, thereby providing a complement to the current AD diagnostic framework.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261450474","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:52:32Z","timestamp":1779699152000},"page":"243-255","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["YWHAG as a novel biomarker in Alzheimer's disease biological research framework"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1014-5112","authenticated-orcid":false,"given":"Qing-Fei","family":"Zhao","sequence":"first","affiliation":[{"name":"Qingdao Municipal Hospital"},{"name":"(Qingdao Municipal 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