{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:24:16Z","timestamp":1791228256781,"version":"4.1.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The logopenic variant of primary progressive aphasia (lvPPA) is a language-led neurodegenerative syndrome commonly associated with Alzheimer's disease pathology and temporo-parietal degeneration. Although acalculia has been reported in lvPPA, numerical cognition has not been systematically investigated, and the specific profile of impairment remains poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize numerical cognition impairment in lvPPA using a comprehensive, theory-driven assessment battery and to examine its clinical relevance for diagnosis and cognitive characterization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fourteen individuals with lvPPA and twenty-eight demographically matched healthy controls completed the dCALQ, a standardized battery assessing number recognition and comprehension, number production (transcoding), and calculation. Participants also underwent global cognitive screening (Montreal Cognitive Assessment), language assessment (Detection Test for Language Impairments in Adults and the Aged), and measures of working memory and executive functioning. Group comparisons, intra-group domain analyses, correlation analyses, and receiver operating characteristic (ROC) analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Individuals with lvPPA showed significant impairments across all numerical domains compared with controls, with the most severe deficits in calculation, followed by transcoding, and milder impairment in number recognition and comprehension. Within the lvPPA group, performance differed significantly across domains, revealing a graded pattern of impairment. ROC analyses demonstrated excellent diagnostic accuracy for the dCALQ total score and strong discrimination for the calculation and transcoding domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Numerical impairment is a robust and systematic feature of lvPPA rather than an incidental finding. The distinct numerical profile identified highlights the contribution of parietal-based cognitive dysfunction and supports the clinical utility of structured numerical assessment for cognitive characterization and diagnosis in dementia syndromes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261450931","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:49:45Z","timestamp":1779698985000},"page":"416-426","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond language: A structured profile of number processing impairment in logopenic primary progressive aphasia"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6661-430X","authenticated-orcid":false,"given":"Jo\u00ebl","family":"Macoir","sequence":"first","affiliation":[{"name":"\u00c9cole des Sciences de la R\u00e9adaptation, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"},{"name":"Centre de Recherche CERVO\u2014Brain Research Centre, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Chaire de recherche sur les aphasies primaires progressives, Fondation de la Famille Lemaire, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Robert","family":"Laforce","sequence":"additional","affiliation":[{"name":"Chaire de recherche sur les aphasies primaires progressives, Fondation de la Famille Lemaire, Qu\u00e9bec, Qu\u00e9bec, Canada"},{"name":"D\u00e9partement des Sciences Neurologiques, Clinique Interdisciplinaire de M\u00e9moire (CIME) du CHU de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000320506.79811.da"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26388"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-024-01958-w"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-90116-x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25333"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101760"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac208"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00227"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/02643290244000239"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00014.2024"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1037\/0003-066X.50.5.351"},{"key":"e_1_3_3_14_2","first-page":"583","volume-title":"Handbook of Clinical and Experimental Neuropsychology","author":"Miceli G","year":"1998","unstructured":"Miceli G, Capasso R. 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