{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:45:33Z","timestamp":1782812733123,"version":"3.54.5"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Perivascular spaces (PVS) have been associated with neurodegenerative diseases such as Alzheimer's disease (AD); however, the added value of 5.0\u2005T magnetic resonance imaging (MRI) for PVS visualization in AD remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the utility of 5.0\u2005T MRI for PVS in AD patients and healthy controls (HCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 186 participants were enrolled, including 62 AD patients and 124 age- and sex-matched HCs. All AD patients underwent paired 3.0\u2005T and 5.0\u2005T MRI scans on the same day, while 62 HCs underwent only 3.0\u2005T MRI and 62 HCs underwent only 5.0\u2005T MRI. Axial T2-weighted imaging was used for PVS assessment. Evaluations included qualitative and quantitative analysis in the basal ganglia (BG) and centrum semiovale (CSO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In AD patients, 5.0\u2005T MRI demonstrated significantly higher PVS image quality scores and severity scores in the BG and CSO than 3.0\u2005T MRI (p\u2009&lt;\u20090.05). Quantitatively, 5.0\u2005T MRI detected a greater PVS burden, evidenced by increased number, larger volume, longer length, and higher curvature of PVS in the bilateral BG (p\u2009&lt;\u20090.001), and increased number and volume of PVS in the bilateral CSO (p\u2009&lt;\u20090.05) compared to 3.0\u2005T MRI. Furthermore, when compared to HCs using 5.0\u2005T MRI, AD patients exhibited higher PVS severity scores and greater PVS burden in most regions than HCs (p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>5.0\u2005T high-resolution images provide superior image quality for PVS visualization and reveal more detailed morphological information of PVS in AD patients compared to 3.0\u2005T MRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261451167","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:48:04Z","timestamp":1779698884000},"page":"500-512","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Visualization of perivascular spaces in Alzheimer's disease using 5.0\u2005T MRI: A preliminary study"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-9895","authenticated-orcid":false,"given":"Lijun","family":"Dong","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of USTC"},{"name":"Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-936X","authenticated-orcid":false,"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of USTC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2831-9040","authenticated-orcid":false,"given":"Xinyi","family":"Lv","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of 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