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Blood-based AD biomarkers offer a scalable approach to population-level study of AD risk; however, whether neighborhood-level social determinants influence these biomarkers across diverse populations remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize associations between neighborhood disadvantage and AD blood biomarkers in a racially and ethnically diverse community sample of older adults with and without cognitive impairment, and to examine whether these associations differ by race, ethnicity, and cognitive status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Regression models predicting AD biomarkers (amyloid-\u03b2 42\/40 ratio, phosphorylated tau-181, total tau, and neurofilament light chain) from demographics and the Area Deprivation Index (ADI) were fit for 1179 Non-Hispanic White, 1264 Hispanic\/Latino, and 724 Black adults. Models were stratified by cognitive impairment status and fit separately by race and ethnicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Amyloid markers were associated with ADI, but only in cognitively impaired individuals living in highly disadvantaged areas. Total tau was elevated in those from disadvantaged neighborhoods, regardless of cognitive status; however, pTau-181 was not associated with ADI for any group. Significant associations were primarily evident among Black and Hispanic\/Latino older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The social exposome is an important factor in AD research, and findings show associations between neighborhood disadvantage and AD blood biomarkers; however, associations are mainly evident among ethnic\/racial minority older adults living in moderately to severely disadvantaged neighborhoods. More work is needed to understand these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261452660","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:25:36Z","timestamp":1780046736000},"page":"741-752","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations between Alzheimer's disease blood biomarkers and neighborhood disadvantage: A HABS-HD community cohort study"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4439-6604","authenticated-orcid":false,"given":"Justin B.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasha","family":"Rhoads","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of 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