{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:14:25Z","timestamp":1783415665042,"version":"3.54.6"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82271977"],"award-info":[{"award-number":["82271977"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"This work was supported in part by the Key Science and Technology Project of Hainan Province","award":["ZDYF2024SHFZ058"],"award-info":[{"award-number":["ZDYF2024SHFZ058"]}]},{"name":"the Hainan Academician Innovation Platform Fund"},{"name":"the Hainan Province Clinical Medical Center"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is characterized by decreased cerebral blood flow (CBF) and abnormal iron deposition, whereas their relationship remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the spatial pattern of CBF-iron deposition coupling across the AD spectrum and its associations with cognition, plasma biomarkers, and inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>34 AD dementia, 86 mild cognitive impairment (MCI), and 26 cognitively normal (CN) were enrolled. Voxel-wise CBF-susceptibility coupling was calculated using three-dimensional pseudocontinuous arterial spin labeling and quantitative susceptibility mapping (QSM). Whole-brain region-based analyses of CBF, QSM, and CBF-susceptibility coupling were subsequently performed. Correlation and mediation analyses were conducted to evaluate the relationships of CBF-susceptibility coupling with plasma biomarkers, inflammatory factors, and cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CBF was significantly reduced in the AD dementia group and MCI group. No significant group differences were observed in QSM susceptibility. The AD dementia group showed significantly lower CBF-susceptibility coupling in multiple brain regions than CN and MCI groups, which was positively correlated with Mini-Mental State Examination (MMSE), Animal Fluency Test scores, and the plasma amyloid-\u03b2 42\/40 (A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      ) ratio. In the MCI group, coupling values were negatively correlated with IL-2 levels. CBF-susceptibility coupling in the bilateral supplementary motor areas of AD patients partially mediated the association between A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      ratio and MMSE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CBF-susceptibility coupling is significantly decreased in AD dementia and appears more sensitive than single-modality measures, and is associated with cognitive decline, amyloid pathology, and inflammation. These findings suggest that disrupted CBF-iron metabolism coupling may be a pathogenic mechanism underlying cognitive impairment in AD, possibly driven by early neuroinflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261452664","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:45:48Z","timestamp":1779698748000},"page":"753-767","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral blood flow\u2013iron susceptibility decoupling links cognition, amyloid pathology, and neuroinflammation in Alzheimer's disease"],"prefix":"10.1177","volume":"112","author":[{"given":"Xingqun","family":"Wang","sequence":"first","affiliation":[{"name":"Hainan General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Hainan General 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