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In rodents, chronic and acute ethanol increases amyloid-\u03b2 (A\u03b2); however, most of those studies have been limited to a single sex or brain region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study explored how adolescent intermittent ethanol (AIE), alters A\u03b2 in multiple regions of the brain in female and male TgF344-AD rats as they age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From postnatal days 28\u201358, female and male TgF344-AD rats were administered either water (CON) or 5.0\u2005g\/kg ethanol (AIE; 20% ethanol w\/v) via intragastric gavage on a 2-day on\/off cycle. In Experiment 1, A\u03b2 was measured in the medial prefrontal cortex, orbitofrontal cortex (OFC), piriform cortex (PC), entorhinal cortex (EC), ventral hippocampus (vHPC), and dorsal hippocampus (dHPC) in 6- and 10-month-old rats. In Experiment 2, in vivo microdialysis was used in 3-month-old female rats to measure how ethanol directly modulates A\u03b2 levels in the dHPC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the OFC, PC, EC, vHPC, and dHPC, A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      and A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      was higher in 6-month-old female TgF344-AD rats compared to males. However, at 10 months A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      and A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      levels were only elevated in the dHPC of AIE-treated females, compared to all other groups. An acute ethanol challenge at 3 months selectively evoked a sustained increase in interstitial fluid A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      levels in AIE-treated females.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In aged females, the dHPC is a region sensitive to ethanol-associated A\u03b2 pathology. This may be due to disruptions in A\u03b2 clearance in early life, which may have an additive effect on A\u03b2 aggregation over the lifespan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261453081","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:26:02Z","timestamp":1780046762000},"page":"861-874","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Adolescent intermittent ethanol exacerbates amyloid-\u03b2 with age in the dorsal hippocampus of female TgF344-AD rats"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0533-0597","authenticated-orcid":false,"given":"Stephen M.","family":"Day","sequence":"first","affiliation":[{"name":"Binghamton University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Reitz","sequence":"additional","affiliation":[{"name":"Binghamton University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5711-3709","authenticated-orcid":false,"given":"Lisa M.","family":"Savage","sequence":"additional","affiliation":[{"name":"Binghamton University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"2025 Alzheimer\u2019s disease facts and figures","volume":"21","author":"Alzheimer's Association","year":"2025","unstructured":"Alzheimer's Association. 2025 Alzheimer\u2019s disease facts and figures. 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