{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:14:30Z","timestamp":1783415670211,"version":"3.54.6"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Capital Medical University Natural Science Foundation","award":["PYZ23057)"],"award-info":[{"award-number":["PYZ23057)"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61633018, 82020108013"],"award-info":[{"award-number":["61633018, 82020108013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The 2018 NIA-AA framework outlines a six-stage continuum from asymptomatic individuals to severe Alzheimer's disease (AD) dementia, but most Chinese research still focuses on dementia or broad diagnostic categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To map diagnosis, treatment, and care patterns across all six AD clinical stages in China and identify demographic, clinical, treatment and care-related factors associated with disease stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nationwide, open online survey via official media channels targeting patients with clinician-confirmed AD and their caregivers. Data were collected via Questionnaire Star. Descriptive analyses, group comparisons, and ordinal logistic regression were performed to examine factors associated with NIA-AA stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1116 valid responses were analyzed. Most participants were at Stage 2 or higher, with distribution of 0.4%, 9.1%, 16.0%, 24.8%, 26.6%, and 23.0%, across Stage 1-6. Overall, 64.5% had been diagnosed within five years. Neurology (66.4%) and memory clinics (19.2%) were the most frequently visited departments. Donepezil (52.2%) and Memantine (38.8%) were the most common medications, while 34.5% reported engaging in non-pharmacological interventions. Only 1.9% of patients receiving professional dementia institutional care. In logistic regression, disease duration (OR\u202f=\u202f0.724, p\u202f=\u202f0.006), stage at first outpatient visit (OR=\u202f1.843, p\u202f&lt;\u202f0.001), and Donepezil use (OR\u202f=\u202f1.394, p\u202f=\u202f0.003) were independently associated with current NIA-AA stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides the first nationwide, real-world description of diagnosis, treatment, and care across all NIA-AA stages in China. The findings highlight the need for improved primary-care screening, expanded memory-clinic access, and structured caregiver support to promote earlier detection and more equitable, stage-appropriate management of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261453551","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T07:02:57Z","timestamp":1779865377000},"page":"947-958","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Status of diagnosis, treatment, and care of Alzheimer's disease continuum in China: A survey-based analysis"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4869-4251","authenticated-orcid":false,"given":"Lixiao","family":"Hao","sequence":"first","affiliation":[{"name":"Xuanwu Hospital of Capital Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xing","sequence":"additional","affiliation":[{"name":"University of Nottingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0377-7424","authenticated-orcid":false,"given":"Ying","family":"Han","sequence":"additional","affiliation":[{"name":"Xuanwu Hospital of Capital Medical University"},{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University"},{"name":"Xuanwu Hospital of Capital Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2024-102020"},{"key":"e_1_3_3_3_2","unstructured":"General Office of the National Health Commission. Notice of the general office of the national health commission on the promotion and prevention of Alzheimer\u2019s disease (2023\u20132025). https:\/\/www.gov.cn\/zhengce\/zhengceku\/202306\/content_6886277.htm (2023 accessed 6 December 2024)."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.05.017"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2024.05.012"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14091"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.70032"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01586-6"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu16172879"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102599"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.27055"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2021-104955"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.927128"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220267"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214564"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2023.101061"},{"key":"e_1_3_3_19_2","article-title":"Chronic stress, social support, and Alzheimer's blood-based biomarkers in the HABS-HD study","volume":"21","author":"Lee JK","year":"2025","unstructured":"Lee JK, Johnson L, Hall JR, et al. 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