{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:51:08Z","timestamp":1790869868014,"version":"4.1.0"},"reference-count":76,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1\/R01AG072637"],"award-info":[{"award-number":["RF1\/R01AG072637"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Midlife obesity is considered one of the top modifiable risk factors for dementia and Alzheimer's disease (AD). However, body mass index (BMI) on its own does not fully represent obesity-associated risks and it is crucial to disentangle the role of body adiposity and its localization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the relationship of MRI-derived body adiposity metrics with AD-related pathology at midlife.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety-seven cognitively normal midlife individuals underwent brain amyloid and tau PET, body MRI, and metabolic and cognitive assessments. Key measures included hepatic fat fraction, visceral (VAT) and subcutaneous adipose tissue (SAT) volumes, and thigh muscle and adiposity. The correlation between adiposity\/metabolic measurements and amyloid\/tau pathologies was investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The average age of participants was 49.8 years, 65.3% were female and 53.6% had obesity. Amyloid PET burden in Centiloids correlated with VAT (rho\u2009=\u20090.36, p\u2009=\u20090.002), BMI (rho\u2009=\u20090.33, p\u2009=\u20090.002), SAT (rho\u2009=\u20090.33, p\u2009=\u20090.002), and insulin resistance (IR) (rho\u2009=\u20090.34, p\u2009=\u20090.003) in females and Whites, lower high-density lipoprotein (HDL) cholesterol (rho\u2009=\u2009\u22120.36, p\u2009=\u20090.002) irrespective of sex and race, and lower MMSE scores (rho\u2009=\u2009\u22120.57, p\u2009=\u20090.043) in only in African-Americans, after correction for age, sex, and education. There was no evidence that HDL nor IR mediated VAT-related amyloid. VAT\/SAT ratio was significantly associated with mean cortical tau SUVR (\u03b2\u2009=\u20090.138, p\u2009=\u20090.030) after adjustment for age, sex, education, and amyloid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among fat depots in our study, visceral fat was more strongly correlated to amyloid pathology, and this association is present even independent from BMI. Also, higher visceral compared to subcutaneous fat is related to higher tau pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261455657","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:21:26Z","timestamp":1780730486000},"page":"991-1003","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Abdominal adiposity and Alzheimer's disease imaging markers across sex and race at midlife"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-9462","authenticated-orcid":false,"given":"Mahsa","family":"Dolatshahi","sequence":"first","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K.","family":"Commean","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahshid","family":"Naghashzadeh","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Hosseinzadeh","family":"Kassani","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Xu","sequence":"additional","affiliation":[{"name":"Washington University in St Louis School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9434-7907","authenticated-orcid":false,"given":"Jingxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Washington University in St Louis School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0616-1780","authenticated-orcid":false,"given":"Soheil","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakisha","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlyn","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby Mcbee","family":"Kemper","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Hantler","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaney","family":"Flores","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Weeks","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lael K.","family":"Ceriani","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude B.","family":"Sirlin","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Ippolito","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"},{"name":"Washington University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiying","family":"Dai","sequence":"additional","affiliation":[{"name":"State University of New York at Binghamton"},{"name":"State University of New York at Binghamton"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Mittendorfer","sequence":"additional","affiliation":[{"name":"University of Missouri School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne E.","family":"Schindler","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"},{"name":"Washington University School of Medicine, St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Brier","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"},{"name":"Washington University School of Medicine, St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"},{"name":"Washington University School of Medicine, St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie L. S.","family":"Benzinger","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"},{"name":"Washington University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9086-0105","authenticated-orcid":false,"given":"Cyrus A.","family":"Raji","sequence":"additional","affiliation":[{"name":"Washington University in St Louis"},{"name":"Washington University School of Medicine"},{"name":"Washington University School of Medicine, St Louis"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(21)00140-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1001\/jama.2022.11058","article-title":"Obesity is now the top modifiable dementia risk factor in the US","volume":"328","author":"Slomski A","year":"2022","unstructured":"Slomski A. Obesity is now the top modifiable dementia risk factor in the US. JAMA 2022; 328: 10\u201310.","journal-title":"JAMA"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00830-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150987"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190154"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.3090"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glac233"},{"key":"e_1_3_3_10_2","unstructured":"Berg S. AMA: Use of BMI alone is an imperfect clinical measure https:\/\/www.ama-assn.org\/delivering-care\/public-health\/ama-use-bmi-alone-imperfect-clinical-measure (2023 accessed June 14 2023)."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13719"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220998"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.52096"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1041"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1656"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1144834"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.157906"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16788-x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100992"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2012.10.014"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21168-5"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12901"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17206"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18419"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.08.028"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019181012"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12030258"},{"key":"e_1_3_3_28_2","first-page":"1843","article-title":"Alzheimer disease pathology and neurodegeneration in midlife obesity: a pilot study","volume":"15","author":"Dolatshahi M","year":"2024","unstructured":"Dolatshahi M, Commean PK, Rahmani F, et al. Alzheimer disease pathology and neurodegeneration in midlife obesity: a pilot study. Aging Dis 2024; 15: 1843\u20131854.","journal-title":"Aging Dis"},{"key":"e_1_3_3_29_2","first-page":"1831","article-title":"Visceral and subcutaneous abdominal fat predict brain volume loss at midlife in 10,001 individuals","volume":"15","author":"Raji CA","year":"2024","unstructured":"Raji CA, Meysami S, Hashemi S, et al. Visceral and subcutaneous abdominal fat predict brain volume loss at midlife in 10,001 individuals. Aging Dis 2024; 15: 1831\u20131842.","journal-title":"Aging Dis"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00316-4"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0310-7"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.7.1135"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.07.012"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22791"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22169"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12668"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0478-z"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073377"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-024-01403-1"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2021.111563"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac299"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191216"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220529"},{"key":"e_1_3_3_45_2","first-page":"1843","article-title":"Alzheimer disease pathology and neurodegeneration in midlife obesity: a pilot study","volume":"15","author":"Dolatshahi M","year":"2024","unstructured":"Dolatshahi M, Commean PK, Rahmani F, et al. Alzheimer disease pathology and neurodegeneration in midlife obesity: a pilot study. Aging Dis 2024; 15: 1843\u20131854.","journal-title":"Aging Dis"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.03.002"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24004"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3246"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-017-0236-7"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01342-2"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169356"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.78"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0922"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.70180"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-0162"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01180-2"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0230450100"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01086-5"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200853"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-05040-3"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00241"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1186\/2042-6410-3-13"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03772.x"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-311"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-020-00701-5"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.088450"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07850-9"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17206"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13020245"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-62918-y"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.937"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05728-8"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.14283\/jfa.2024.39"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-024-00578-9"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnab182"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.4501"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201704-0704OC"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261455657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261455657","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261455657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:25:20Z","timestamp":1783412720000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261455657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,6]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/13872877261455657"],"URL":"https:\/\/doi.org\/10.1177\/13872877261455657","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,6]]}}}