{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:31:27Z","timestamp":1786379487826,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Alzheimer's disease is the leading cause of dementia and constitutes a major public health problem. Recent research suggests that certain chronic infections, particularly periodontal infections, may play a role in the development or progression of this disease. Among the bacteria involved in periodontal disease,\n                      <jats:italic toggle=\"yes\">Porphyromonas gingivalis<\/jats:italic>\n                      has attracted particular attention from researchers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      In this way, the aim of this thesis, conducted in the form of a scoping review, was to analyze existing scientific data on the relationship between\n                      <jats:italic toggle=\"yes\">Porphyromonas gingivalis<\/jats:italic>\n                      infection and Alzheimer's disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To achieve this, a literature search was conducted in several scientific databases leading to the selection of fourteen studies that met the inclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Some of the selected studies have shown the presence of\n                      <jats:italic toggle=\"yes\">Porphyromonas gingivalis<\/jats:italic>\n                      or its virulence factors in the brain tissues of patients with Alzheimer's disease. Experimental studies also indicate that this bacterium can promote certain mechanisms involved in neurodegeneration, namely inflammation and accumulation of amyloid-\u03b2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Selected studies point to the existence of an association between exposure to periodontal bacteria and an increased risk of developing Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261456716","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:14:55Z","timestamp":1780996495000},"page":"1114-1126","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship between\n                    <i>Porphyromonas gingivalis<\/i>\n                    infection and the development of Alzheimer's disease: A scoping review"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0693-9831","authenticated-orcid":false,"given":"In\u00eas","family":"Lopes Cardoso","sequence":"first","affiliation":[{"name":"Fernando Pessoa University"},{"name":"Fernando Pessoa University"},{"name":"FP-I3ID, Institute of Investigation, Innovation and Development, FP-BHS, Biomedical and Health Sciences, University Fernando Pessoa, Porto, Portugal"},{"name":"Escola de Medicina e Ci\u00eancias Biom\u00e9dicas (EMCB), Fernando Pessoa Teaching and Culture Foundation, Gondomar, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3687-7798","authenticated-orcid":false,"given":"Maria In\u00eas","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Fernando Pessoa University"},{"name":"Fernando Pessoa University"},{"name":"FP-I3ID, Institute of Investigation, Innovation and Development, FP-BHS, Biomedical and Health Sciences, University Fernando Pessoa, Porto, Portugal"},{"name":"Escola de Medicina e Ci\u00eancias Biom\u00e9dicas (EMCB), Fernando Pessoa Teaching and Culture Foundation, Gondomar, Portugal"},{"name":"INMLCF, I. P., North Delegation - National Institute of Legal Medicine and Forensic Sciences, I. P., Porto, Portugal"},{"name":"CEISUC, Centre of Investigation in Technologies and Centre for Health Studies and Research of the University of Coimbra, Coimbra, Portugal"},{"name":"CIBB- Centre for Inovation in Biomedicine and Biotechnology, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Tubiana","sequence":"additional","affiliation":[{"name":"Fernando Pessoa University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2430-1241","authenticated-orcid":false,"given":"Sandra","family":"Gavinha","sequence":"additional","affiliation":[{"name":"Fernando Pessoa University"},{"name":"Fernando Pessoa University"},{"name":"FP-I3ID, Institute of Investigation, Innovation and Development, FP-BHS, Biomedical and Health Sciences, University Fernando Pessoa, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau3333"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14141"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75517-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200393"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-6988.2005.00026.x"},{"key":"e_1_3_3_7_2","first-page":"792519","article-title":"Translational science and evidence-based healthcare: a clarification and reconceptualization of how knowledge is generated and used in healthcare","volume":"2012","author":"Pearson A","year":"2012","unstructured":"Pearson A, Jordan Z, Munn Z. 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