{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:31:32Z","timestamp":1786379492090,"version":"build-2736575974"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["BMRP849"],"award-info":[{"award-number":["BMRP849"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2314-B-182-035-MY3"],"award-info":[{"award-number":["NSTC 113-2314-B-182-035-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early Alzheimer's disease (AD)-related cognitive vulnerability is characterized by subtle disruptions in attentional and executive processing that may precede overt declines in global cognitive scores. Identifying process-sensitive behavioral markers capable of capturing these early alterations remains a major challenge in psychogeriatric assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine whether eye-movement\u2013derived process-level measures, particularly fixation-shift dynamics, are associated with early cognitive vulnerability in older adults and whether they provide incremental value beyond conventional cognitive screening scores in an AD-related context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study enrolled 109 adults aged \u226565 years, categorized as cognitively normal (CN, n\u2009=\u200933), mild cognitive impairment (MCI, n\u2009=\u200935), and dementia due to AD (ADD, n\u2009=\u200941). Participants completed a standardized online interactive cognitive task while eye movements were recorded using a non\u2013head-fixed, desktop-based eye-tracking system. Cognitive-only, eye-movement\u2013only, and combined multimodal models were compared using receiver operating characteristic (ROC) analysis and area under the curve (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The combined multimodal model consistently outperformed single-modality approaches. Discriminative performance was high for CN versus ADD (AUC\u2009=\u20090.925) and for CN versus cognitively impaired participants overall (AUC\u2009=\u20090.897). Fixation-shift dynamics emerged as a robust process-level marker, demonstrating particular sensitivity in distinguishing CN individuals from those with MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fixation-shift eye-movement dynamics capture early AD-related cognitive vulnerability beyond conventional total cognitive scores. This multimodal framework may support psychogeriatric screening and clinical triage by detecting subtle cognitive inefficiencies that precede measurable declines on standard cognitive tests.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261457344","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:51:31Z","timestamp":1782827491000},"page":"1219-1229","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Process-level eye-movement dynamics enhance sensitivity to early Alzheimer's disease-related cognitive vulnerability"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9121-3655","authenticated-orcid":false,"given":"Ping-Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Chang Gung University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wann-Yun","family":"Shieh","sequence":"additional","affiliation":[{"name":"Chang Gung University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Cheng","family":"Weng","sequence":"additional","affiliation":[{"name":"Chang Gung University"},{"name":"Chang Gung Medical Foundation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9678-8215","authenticated-orcid":false,"given":"Hsiu-Hsin","family":"Tsai","sequence":"additional","affiliation":[{"name":"Chang Gung University"},{"name":"New Taipei Municipal TuCheng Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Taoyuan General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yih","family":"Liu","sequence":"additional","affiliation":[{"name":"New Taipei Municipal TuCheng Hospital"},{"name":"Chang Gung University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. Global status report on the public health response to dementia. https:\/\/www.who.int\/publications\/i\/item\/9789240033245 (2021 accessed 26 April 2025)."},{"key":"e_1_3_3_3_2","unstructured":"Ministry of Health and Welfare (Taiwan). National community-based epidemiological survey of dementia in Taiwan 2024. (in Chinese) https:\/\/www.mohw.gov.tw\/cp-6653-78102-1.html (2024 accessed 26 April 2025)."},{"key":"e_1_3_3_4_2","unstructured":"Taiwan Alzheimer\u2019s Disease Association. Estimated number of people with dementia in Taiwan 2023. (in Chinese) https:\/\/www.tada2002.org.tw\/Messages\/Content?Id=1207 (2023 accessed 26 April 2025)."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics6010006"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2020.22"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113974"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-015-0103-3"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05716-y"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215551"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117529"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610211002298"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610214002269"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1123456"},{"key":"e_1_3_3_18_2","unstructured":"Gazepoint. 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