{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:31:29Z","timestamp":1786379489028,"version":"build-2736575974"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The interplay between Alzheimer's disease (AD) and the cardiovascular system remains poorly understood. While vascular factors influencing AD have been studied, whether AD pathology conversely affects blood pressure regulation is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated whether baseline plasma AD biomarkers predict subsequent visit-to-visit blood pressure variability (BPV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective analysis included 470 community-based older adults from the Health and Aging Brain Study-Health Disparities (HABS-HD) cohort. Multiple linear regression models separately assessed associations between each baseline plasma AD biomarker (A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      ratio, total tau, p-tau181, NfL) and follow-up BPV, with progressive adjustments for demographics, clinical diagnosis, cardiovascular risk factors, and mean blood pressure. In fully adjusted models, all plasma AD biomarkers were included simultaneously to adjust for potential mutual confounding and identify independent associations. Subgroup and sensitivity analyses were conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In fully adjusted models, total tau remained independently associated with higher systolic blood pressure variability (\u03b2\u2009=\u20093.94, 95%CI: 1.00\u20136.87, p\u2009=\u20090.009). These associations were particularly prominent in males (\u03b2\u2009=\u20095.80, 95% CI: 1.66\u20139.95, p\u2009=\u20090.007), non-Hispanic White (\u03b2\u2009=\u20094.00, 95% CI: 0.12\u20137.88, p\u2009=\u20090.044), cognitively unimpaired individuals (\u03b2\u2009=\u20094.42, 95% CI: 1.14\u20137.70, p\u2009=\u20090.009), APOE \u03b54 non-carriers (\u03b2\u2009=\u20094.91, 95% CI: 1.42\u20137.70, p\u2009=\u20090.009), and individuals not using antihypertensive medication (\u03b2\u2009=\u20094.29, 95% CI: 0.71\u20137.87, p\u2009=\u20090.020). Sensitivity analyses confirmed robustness of findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plasma total tau independently predicts BPV, especially during pre-clinical AD stages. This finding reveals an important connection between AD pathology and vascular dysregulation, supporting the paradigm of AD as a systemic disorder and providing new directions for early risk identification and intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261457455","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:37:08Z","timestamp":1780637828000},"page":"1230-1239","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Alzheimer's disease blood-based biomarkers and visit-to-visit blood pressure variability: The HABS-HD study"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1280-1328","authenticated-orcid":false,"given":"Jinfeng","family":"Deng","sequence":"first","affiliation":[{"name":"The Fifth Affiliated Hospital of Sun Yat-sen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songbiao","family":"Li","sequence":"additional","affiliation":[{"name":"The Fifth Affiliated Hospital of Sun Yat-sen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Health and Aging Brain Study (HABS-Hd) Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-025-01399-z"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14233"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-025-01866-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2021.7009"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.06.054"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.029297"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccb.2025.100392"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17797"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.70066"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20627-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13290"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.11.017"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci15050502"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2174\/1567205013666160606100509"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00529"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000340"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2022.102105"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251392604"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251415367"},{"key":"e_1_3_3_23_2","article-title":"Association of cardiovascular risk factors and blood biomarkers with cognition: the HABS-HD study","volume":"15","author":"Jiang X","year":"2023","unstructured":"Jiang X, O'Bryant SE, Johnson LA, et al. Association of cardiovascular risk factors and blood biomarkers with cognition: the HABS-HD study. Alzheimers Dement (Amst) 2023; 15: e12394.","journal-title":"Alzheimers Dement (Amst)"},{"key":"e_1_3_3_24_2","article-title":"Health and Aging Brain Study\u2013Health Disparities (HABS-HD) methods and partner characteristics","volume":"11","author":"Petersen ME","year":"2025","unstructured":"Petersen ME, Zhou Z, Hall JR, et al. Health and Aging Brain Study\u2013Health Disparities (HABS-HD) methods and partner characteristics. Alzheimers Dement (N Y) 2025; 11: e70140.","journal-title":"Alzheimers Dement (N Y)"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-025-01845-0"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70733"},{"key":"e_1_3_3_27_2","article-title":"Chronic stress, social support, and Alzheimer\u2019s blood-based biomarkers in the HABS-HD study","volume":"21","author":"Lee JK","year":"2025","unstructured":"Lee JK, Johnson L, Hall JR, et al. Chronic stress, social support, and Alzheimer\u2019s blood-based biomarkers in the HABS-HD study. Alzheimers Dement 2025; 21: e70043.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_28_2","article-title":"The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics","volume":"13","author":"O\u2019Bryant SE","year":"2021","unstructured":"O\u2019Bryant SE, Johnson LA, Barber RC, et al. The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics. Alzheimers Dement (Amst) 2021; 13: e12202.","journal-title":"Alzheimers Dement (Amst)"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70327"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1607646"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.40249"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz123"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103409"},{"key":"e_1_3_3_35_2","doi-asserted-by":"crossref","unstructured":"Zhao K Xie H Jacobs T et al. Elucidating the neuropathological and molecular heterogeneity of amyloid-beta and tau in Alzheimer\u2019s disease through machine learning and transcriptomic integration. bioRxiv 2024; 2024.10.16.618708.","DOI":"10.1101\/2024.10.16.618708"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2020.01.026"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.02.007"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-75"},{"key":"e_1_3_3_39_2","article-title":"High visit-to-visit blood pressure variability predicts global cognitive decline: the Multi-Ethnic Study of Atherosclerosis","volume":"8","author":"Daniel GD","year":"2022","unstructured":"Daniel GD, Chen H, Bertoni AG, et al. High visit-to-visit blood pressure variability predicts global cognitive decline: the Multi-Ethnic Study of Atherosclerosis. Alzheimers Dement (N Y) 2022; 8: e12342.","journal-title":"Alzheimers Dement (N Y)"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-021-00533-w"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261457455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261457455","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261457455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:15:01Z","timestamp":1786378501000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261457455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/13872877261457455"],"URL":"https:\/\/doi.org\/10.1177\/13872877261457455","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]}}}