{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:31:22Z","timestamp":1786379482267,"version":"build-2736575974"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While chronological age is a major but non-specific risk factor for dementia, measures of biological age based on physiological biomarkers may more accurately reflect systemic aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to assess the association between a Gompertz law-based biological age (Light BioAge) and incident dementia in a national cohort of middle-aged and older adults in China, and to evaluate the potential modifying role of lifestyle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a longitudinal analysis of 5641 participants (\u226545 years) from China Health and Retirement Longitudinal Study. Light BioAge was computed at baseline (2011) using a validated algorithm incorporating chronological age, serum creatinine, fasting glucose, and high-sensitivity C-reactive protein. Dementia in 2018 was determined via cognitive tests, informant reports, and functional assessment. Logistic regression models were used to estimate odds ratios (ORs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the follow-up, 788 (13.97%) participants were identified as having dementia. Each 1-year increment in Light BioAge was associated with 4% higher risk of dementia (OR 1.04, 95% CI 1.03\u20131.05). Compared to low BioAge, participants with high BioAge had a more than two-fold higher risk of dementia (OR 2.38, 95% CI 1.85\u20133.04). This association persisted across strata of favorable and unfavorable lifestyles. Joint exposure analysis revealed that individuals with both high BioAge and an unfavorable lifestyle faced the highest risk (OR 2.96, 95% CI 2.05\u20134.27).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Accelerated biological aging, quantified by Light BioAge, is a robust independent risk factor for dementia. Favorable lifestyle interventions offer potential strategies. However, findings require caution given the observational design and non-clinical dementia measure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261457952","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:52:27Z","timestamp":1781614347000},"page":"1332-1339","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between Gompertz law-based biological age and dementia: A longitudinal study of middle-aged and older Chinese adults"],"prefix":"10.1177","volume":"112","author":[{"given":"Hua","family":"Liu","sequence":"first","affiliation":[{"name":"West China Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cheng","sequence":"additional","affiliation":[{"name":"West China Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2768-8736","authenticated-orcid":false,"given":"Chaofeng","family":"Fan","sequence":"additional","affiliation":[{"name":"West China Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1678212"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2024-102020"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13004"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2021.01.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95425-5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70221"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213616"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03640-4"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26900"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213794"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-024-00438-8"},{"key":"e_1_3_3_13_2","article-title":"Gompertz law-based biological age (GOLD BioAge): a simple and practical measurement of biological ageing to capture morbidity and mortality risks","volume":"12","author":"Hao M","year":"2025","unstructured":"Hao M, Zhang H, Wu J, et al. Gompertz law-based biological age (GOLD BioAge): a simple and practical measurement of biological ageing to capture morbidity and mortality risks. Adv Sci (Weinh) 2025; 12: e01765.","journal-title":"Adv Sci (Weinh)"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-024-00745-w"},{"key":"e_1_3_3_15_2","first-page":"88","article-title":"Effect of modifiable lifestyle factors on biological aging","volume":"13","author":"Lu WH","year":"2024","unstructured":"Lu WH. Effect of modifiable lifestyle factors on biological aging. JAR Life 2024; 13: 88\u201392.","journal-title":"JAR Life"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys203"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00691-6"},{"key":"e_1_3_3_18_2","article-title":"Temporal trend in dementia incidence since 2002 and projections for prevalence in England and Wales to 2040: modelling study","volume":"358","author":"Ahmadi-Abhari S","year":"2017","unstructured":"Ahmadi-Abhari S, Guzman-Castillo M, Bandosz P, et al. Temporal trend in dementia incidence since 2002 and projections for prevalence in England and Wales to 2040: modelling study. 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