{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:31:24Z","timestamp":1786379484190,"version":"build-2736575974"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Korea Drug Development Fund funded by the Ministry of Science and ICT; Ministry of Trade, Industry and Energy; and Ministry of Health and Welfare, Republic of Korea","award":["RS-2021-DD121403 (1711200672)"],"award-info":[{"award-number":["RS-2021-DD121403 (1711200672)"]}]},{"name":"Korea Dementia Research Center funded by the Ministry of Science and ICT; Ministry of Health and Welfare; and Korea Health Industry Development Institute, Republic of Korea","award":["RS-2023-KH-136029"],"award-info":[{"award-number":["RS-2023-KH-136029"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A major pathological hallmark of Alzheimer's disease (AD), the most common cause of dementia, is the accumulation of amyloid-\u03b2 (A\u03b2) plaques. However, currently approved therapeutic agents fail to fundamentally halt disease progression and have limitations in terms of efficacy, sustainability, and safety. CD300c is an immunoregulatory molecule that modulates monocyte differentiation and activates macrophages. We recently developed a fully human anti-CD300c antibody, CB201, demonstrating its therapeutic potential in early and late 5xFAD mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the efficacy of CB201 in late-stage AD using the APP\/PS1 transgenic mouse model. We analyzed the effects of administering CB201 on changes in memory and cognitive function and A\u03b2 and tau protein accumulation in the brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To assess long- and short-term memory improvements, behavioral tests were conducted using the Morris water maze and fear conditioning. Immunostaining was performed to quantify changes in A\u03b2 and tau accumulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CB201-treated late-stage AD mice demonstrated improved cognitive performance and memory, comparable to wild-type controls. Histopathological analysis further revealed that CB201 treatment reduced A\u03b2 and tau accumulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CB201 exerts significant therapeutic effects on functional impairments and pathological alterations in late-stage AD. These results confirm CB201 as a potential immunotherapeutic for the treatment of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261458360","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:07:16Z","timestamp":1782277636000},"page":"1353-1361","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel antibody against CD300c ameliorates cognitive deficits and reduces pathology in the late-stage of APP\/PS1 mouse model"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7890-6871","authenticated-orcid":false,"given":"Suin","family":"Lee","sequence":"first","affiliation":[{"name":"CentricsBio, Inc., Seoul, Republic of Korea"},{"name":"Department of Life Sciences, Ewha Womans University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Jo","family":"Choi","sequence":"additional","affiliation":[{"name":"School of Medicine, Kyungpook National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hee","family":"Park","sequence":"additional","affiliation":[{"name":"School of Medicine, Kyungpook National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9583-4273","authenticated-orcid":false,"given":"Sujin","family":"Park","sequence":"additional","affiliation":[{"name":"CentricsBio, Inc., Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongeun","family":"Kim","sequence":"additional","affiliation":[{"name":"CentricsBio, Inc., Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Kyung","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Kyungpook National University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunbo","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Ewha Womans University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4802-3095","authenticated-orcid":false,"given":"Jae-Won","family":"Jeon","sequence":"additional","affiliation":[{"name":"CentricsBio, Inc., Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Sung","family":"Bae","sequence":"additional","affiliation":[{"name":"School of Medicine, Kyungpook National University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102289"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028035"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.05.004"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.16-3-247"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2025.2546868"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100708"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2023.2178414"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-435057"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2001.057005415.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02657"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4905"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2009.06.004"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2023.152780"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13051169"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-06.2006"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.05.029"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113192"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.05.029"},{"key":"e_1_3_3_21_2","article-title":"Brain-derived neurotrophic factor ameliorates learning deficits in a rat model of Alzheimer\u2019s disease induced by abeta1-42","volume":"10","author":"Zhang L","year":"2015","unstructured":"Zhang L, Fang Y, Lian Y, et al. 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