{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:31:13Z","timestamp":1786379473794,"version":"build-2736575974"},"reference-count":45,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100024740","name":"Turner Institute for Brain and Mental Health, Monash University","doi-asserted-by":"publisher","award":["SPS Strategic Project Grant"],"award-info":[{"award-number":["SPS Strategic Project Grant"]}],"id":[{"id":"10.13039\/501100024740","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2009550"],"award-info":[{"award-number":["GNT2009550"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["23AARF-1025519"],"award-info":[{"award-number":["23AARF-1025519"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In Australia, access to Alzheimer's disease (AD) therapeutics requires apolipoprotein E (\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      ) genotype testing and disclosure, yet the feasibility, acceptability and tolerability of\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      disclosure in an Australian context remains unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This pilot study evaluated a researcher-delivered, videoconferencing-based\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      disclosure protocol in cognitively unimpaired (CU) Australian adults with dementia family history.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The DISCLOSE-\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      protocol, informed by prior expert approaches and Australian consumer preferences, was piloted in fifteen CU adults aged 40\u201370 (8 \u03b54 carriers, 7 non-carriers). The protocol comprised 7 online sessions, including mood\/suicide risk assessment, education, and psychological readiness evaluation.\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      genotype was disclosed 1:1 via videoconferencing using a standardized interaction procedure. Existing data and online questionnaires assessed participant characteristics and outcomes pre- and post-disclosure. Paired-samples t-tests examined within-group mood changes, and independent-samples t-tests compared post-disclosure test-\/event-related distress between carriers and non-carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All participants (M age = 60.8 (\u00b16.4), 60% female) completed the pilot, and no adverse events occurred. Baseline mood was equivalent across groups. Anxiety decreased post-disclosure in both \u03b54 carriers and non-carriers. Depressive symptoms increased slightly but not significantly in \u03b54 carriers and remained sub-threshold. Test-related distress was moderately higher in \u03b54 carriers post-disclosure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Researcher-delivered and remote\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      disclosure via videoconferencing resulted in no attrition nor clinically-significant short-term psychological distress, with pilot data providing preliminary evidence of feasibility, acceptability and tolerability in this cohort. Findings will inform the development and implementation of culturally-appropriate and scalable\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      disclosure protocols in research and clinical settings to facilitate delivery of anti-A\u03b2 therapies in Australia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261459068","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:08:16Z","timestamp":1781849296000},"page":"1552-1565","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pilot feasibility, acceptability, and tolerability of researcher-delivered apolipoprotein E (\n                    <i>APOE<\/i>\n                    ) disclosure via videoconferencing in Australian adults at-risk of dementia"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7600-9277","authenticated-orcid":false,"given":"Emily","family":"Rosenich","sequence":"first","affiliation":[{"name":"Monash University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simran","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Monash University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruby","family":"Haeusler","sequence":"additional","affiliation":[{"name":"Monash University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirette","family":"Keriakes","sequence":"additional","affiliation":[{"name":"Monash University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Cummins","sequence":"additional","affiliation":[{"name":"Monash University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Olver","sequence":"additional","affiliation":[{"name":"Monash University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-6895","authenticated-orcid":false,"given":"Lisa","family":"Bransby","sequence":"additional","affiliation":[{"name":"Monash University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6947-9537","authenticated-orcid":false,"given":"Paul","family":"Maruff","sequence":"additional","affiliation":[{"name":"Monash University"},{"name":"The University of Melbourne"},{"name":"Cogstate Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0308-5156","authenticated-orcid":false,"given":"Yen Ying","family":"Lim","sequence":"additional","affiliation":[{"name":"Monash University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2016.03.012"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000334607"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170072"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.09.013"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31821d69b8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340066035"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00274-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.4046"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988721993575"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.12.007"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988705281883"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809578"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210675"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.10.014"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-021-01149-2"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1418"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2011.0300"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610218002089"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.103"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.70041"},{"key":"e_1_3_3_26_2","unstructured":"Australian Bureau of Statistics. 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