{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:22:23Z","timestamp":1792030943212,"version":"4.4.0"},"reference-count":163,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>The defining features of Alzheimer's disease (AD) include neurodegeneration, a decline in cognition, and tau and amyloid-\u03b2 protein pathologies. Sleep problems affect many individuals with AD and could be an aggravating factor in the disease because it creates a barrier to the glymphatic system's ability to clear neurotoxic proteins, disrupt the plasticity of synapses, and increase neuroinflammation. Suvorexant, which works as a dual orexin receptor antagonist, has proven effective in the management of sleep problems by fine-tuning the orexin system, which regulates arousal. Preliminary studies indicate that, in addition to improving sleep, Suvorexant could potentially help in the reduction of amyloid and tau buildup, as well as the improvement of synaptic activity and reduction of neuroinflammation. Recent clinical studies show improvements in sleep quality among older adults, in addition to safety and efficacy, and suggest increasing cognitive functioning in mild cognitive impairment and early AD. This review summarizes the existing research on the potential of Suvorexant as a therapeutic to address the mechanisms of orexin signaling in AD, as well as the sleep-targeted interventions to address the symptoms and modify the disease to improve cognitive functioning. We also emphasize future research directions such as cognitive outcomes over extended periods, potential optimal dosing, and combinatory strategies with lifestyle and\/or medication therapies. This review will discuss the current evidence regarding the therapeutic effects of suvorexant and orexin signaling in AD.<\/jats:p>","DOI":"10.1177\/13872877261461161","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:16:32Z","timestamp":1781774192000},"page":"1700-1716","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of suvorexant in Alzheimer's disease: Targeting sleep, orexin signaling, and disease pathophysiology"],"prefix":"10.1177","volume":"112","author":[{"given":"Adeel","family":"Ahmed Abbasi","sequence":"first","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sciences"},{"name":"International Center for Neuroscience Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Norouziyan","sequence":"additional","affiliation":[{"name":"International Center for Neuroscience Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9905-6845","authenticated-orcid":false,"given":"Nasrollah","family":"Moradikor","sequence":"additional","affiliation":[{"name":"International Center for Neuroscience Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.50786.1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1453489"},{"key":"e_1_3_3_4_2","volume-title":"StatPearls [Internet]","author":"Lui F","unstructured":"Lui F, Tsao JW, Doerr C. Alzheimer disease (nursing). In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing, 2024.https:\/\/www.ncbi.nlm.nih.gov\/sites\/books\/NBK568805\/."},{"key":"e_1_3_3_5_2","article-title":"The neuropsychology of chronic neurological disorders: a review of cognitive and emotional impairments","volume":"17","author":"Harsh S","year":"2025","unstructured":"Harsh S, Rather HJ, Dwivedi A, et al. The neuropsychology of chronic neurological disorders: a review of cognitive and emotional impairments. Cureus 2025; 17: e93642.","journal-title":"Cureus"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-020-02232-9"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1134\/S002689332104004X"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27103194"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-024-01248-2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00749-z"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020355"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.57078"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00410-4"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2022.07.015"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-14391-3"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19148457"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1372326"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-024-00797-y"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-023-00340-6"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102457"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201582"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11055-024-01585-y"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00019.2024"},{"key":"e_1_3_3_24_2","first-page":"4","article-title":"Influence of sleep disruption on protein accumulation in neurodegenerative diseases","volume":"2","author":"Wang X","year":"2022","unstructured":"Wang X, Wang R, Li J. Influence of sleep disruption on protein accumulation in neurodegenerative diseases. Ageing Neur Dis 2022; 2: 4.","journal-title":"Ageing Neur Dis"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.875138"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101541"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00617-4"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202200237"},{"key":"e_1_3_3_29_2","article-title":"Physiological role of orexin\/hypocretin in the human body in motivated behavior: a comprehensive review","volume":"15","author":"Singh R","year":"2023","unstructured":"Singh R, Biswas DA, Biswas D. Physiological role of orexin\/hypocretin in the human body in motivated behavior: a comprehensive review. Cureus 2023; 15: e34009.","journal-title":"Cureus"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-022-00700-3"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2024.149408"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1590556"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.984227"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphyss.2024.100004"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.07.007"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.70009"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphyss.2024.100004"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-025-06839-2"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2020.0136"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-025-06839-2"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107680209500503"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1697406"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.100166"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1770805"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13902"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26178700"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S201994"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2023.101746"},{"key":"e_1_3_3_49_2","first-page":"67898","article-title":"Suvorexant, a novel dual orexin receptor antagonist, for the management of insomnia","volume":"10","author":"Han AH","year":"2023","unstructured":"Han AH, Burroughs CR, Falgoust EP, et al. Suvorexant, a novel dual orexin receptor antagonist, for the management of insomnia. Health Psychol Res 2023; 10: 67898.","journal-title":"Health Psychol Res"},{"key":"e_1_3_3_50_2","first-page":"1","volume-title":"Neurochemistry and clinical disorders: circuitry of some psychiatric and psychosomatic syndromes","author":"Lechin F","year":"1989","unstructured":"Lechin F, van der Dijs B, Amat J, et al. Neuroanatomical basis. In: Lechin F, van der Dijs B (eds) Neurochemistry and clinical disorders: circuitry of some psychiatric and psychosomatic syndromes. CRC Press, 1989, pp.1\u201348."},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-023-01055-y"},{"key":"e_1_3_3_52_2","first-page":"8","article-title":"A comprehensive review of dual orexin receptor antagonist (DORA), Daridorexant: novel drug for sleep and related disorders","volume":"1","author":"Misra S","year":"2024","unstructured":"Misra S. A comprehensive review of dual orexin receptor antagonist (DORA), Daridorexant: novel drug for sleep and related disorders. Therapy 2024; 1: 8.","journal-title":"Therapy"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1188306"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-025-01770-2"},{"key":"e_1_3_3_55_2","unstructured":"Morais dos Santos S. Exploring the intersection of artificial intelligence in understanding Alzheimer\u2019s Disease: the role of the circadian clock and orexin receptors. Master's Thesis Universidade de Lisboa Portugal 2024."},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-025-09382-9"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02096-3"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44323-025-00025-5"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-040323-031929"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26641"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-2557-8422"},{"key":"e_1_3_3_62_2","unstructured":"Oliveira PA. The impact of sleep-wake interventions on neuropathology and cognition in a mouse model of dementia. PhD Thesis University of Surrey UK 2021."},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-025-13456-8"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.02.020"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16212"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v11.i11.954"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-88907-3_6"},{"key":"e_1_3_3_68_2","first-page":"59","article-title":"Circadian rhythm disruption and sleep disorders in Alzheimer\u2019s disease: mechanistic insights and therapeutic potentials","volume":"46","author":"Liu K","year":"2025","unstructured":"Liu K. Circadian rhythm disruption and sleep disorders in Alzheimer\u2019s disease: mechanistic insights and therapeutic potentials. Neuroendocrinol Lett 2025; 46: 59\u201369.","journal-title":"Neuroendocrinol Lett"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26125541"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1159\/000514960"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2025.1529981"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58020274"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2025.112769"},{"key":"e_1_3_3_74_2","article-title":"A review of recent advances in the management of Alzheimer\u2019s disease","volume":"16","author":"Thangwaritorn S","year":"2024","unstructured":"Thangwaritorn S, Lee C, Metchikoff E, et al. A review of recent advances in the management of Alzheimer\u2019s disease. Cureus 2024; 16: e58416.","journal-title":"Cureus"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13229"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12035"},{"key":"e_1_3_3_77_2","article-title":"Management of sleep disturbance related to Alzheimer disease and dementia: an updated review of ClinicalTrials","volume":"104","author":"Aldurdunji MM","year":"2025","unstructured":"Aldurdunji MM. Management of sleep disturbance related to Alzheimer disease and dementia: an updated review of ClinicalTrials. gov. Medicine 2025; 104: e43725.","journal-title":"gov. Medicine"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852924000336"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.6614"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-021-00891-1"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006737"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph14040383"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230933"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-023-01258-2"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2024.09.016"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.12793\/tcp.2024.32.e5"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.7.893"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.64719\/pb.4429"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13406"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1230428"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322100"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.763573"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00819-2"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsae098"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsae025"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12738"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.9740\/mhc.2023.10.244"},{"key":"e_1_3_3_98_2","first-page":"56","article-title":"Efficacy and safety profile of suvorexant for the treatment of insomnia","volume":"21","author":"Sabat A","year":"2025","unstructured":"Sabat A, Garg A, Khan MA. Efficacy and safety profile of suvorexant for the treatment of insomnia. Curr Drug Saf 2025; 21: 56\u201368.","journal-title":"Curr Drug Saf"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000932"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1263771"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.06.012"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-022-00980-8"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11055-024-01585-y"},{"key":"e_1_3_3_104_2","article-title":"Glymphatic system dysfunction: a link between sleep disorders and neurodegeneration","author":"Yang H","unstructured":"Yang H, Tian X, Luo X, et al. Glymphatic system dysfunction: a link between sleep disorders and neurodegeneration. Psychopharmacology (Berl). Epub ahead of print 24 Jan 2026. DOI: https:\/\/doi.org\/10.1007\/s00213-026-07004-z","journal-title":"Psychopharmacology (Berl)"},{"key":"e_1_3_3_105_2","unstructured":"Assis DSL. In silico discovery and optimization of small molecules targeting neurodegenerative diseases. Master's Degree Universidade de Lisboa Portugal 2024."},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00019.2024"},{"key":"e_1_3_3_107_2","unstructured":"Pivac LN. Sleep Improvement: A Preventative Therapy to Reduce the Risk for Cognitive Decline. PhD Thesis Murdoch University Australia 2025."},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abh4284"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom14010093"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12111676"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dscb.2025.100187"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-025-00638-9"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1668480"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2025.2573364"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20982388"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01207-8"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.08.025"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12723"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25063160"},{"key":"e_1_3_3_120_2","unstructured":"Colombo G. Orexinergic and cholinergic function in the brain ascending modulatory system and its implications in sleep-related pathologies. PhD Thesis Universit\u00e0 degli Studi di Milano-Bicocca Italy 2022."},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00109-w"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02096-3"},{"key":"e_1_3_3_123_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11082092"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-00435-y"},{"key":"e_1_3_3_125_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph18121879"},{"key":"e_1_3_3_126_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.10673"},{"key":"e_1_3_3_127_2","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251392186"},{"key":"e_1_3_3_128_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-024-03978-5"},{"key":"e_1_3_3_129_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13325"},{"key":"e_1_3_3_130_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvad139"},{"key":"e_1_3_3_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105322"},{"key":"e_1_3_3_132_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.70984"},{"key":"e_1_3_3_133_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.96"},{"key":"e_1_3_3_134_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.14399"},{"key":"e_1_3_3_135_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14060598"},{"key":"e_1_3_3_136_2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyaf025"},{"key":"e_1_3_3_137_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-023-04086-5"},{"key":"e_1_3_3_138_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-09404-1"},{"key":"e_1_3_3_139_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03460-8"},{"key":"e_1_3_3_140_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13654"},{"key":"e_1_3_3_141_2","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2019-0058"},{"key":"e_1_3_3_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.11.001"},{"key":"e_1_3_3_143_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2469-20.2020"},{"key":"e_1_3_3_144_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26188980"},{"key":"e_1_3_3_145_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-025-03421-0"},{"key":"e_1_3_3_146_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab272"},{"key":"e_1_3_3_147_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9798894551968.lg08"},{"key":"e_1_3_3_148_2","first-page":"459","article-title":"Sleep: architecture, deprivation, and propofol-induced sleep","volume":"92","author":"McClintock KT","year":"2024","unstructured":"McClintock KT, Mercurio AK, Reilly DS, et al. Sleep: architecture, deprivation, and propofol-induced sleep. AANA J 2024; 92: 459\u2013470.","journal-title":"AANA J"},{"key":"e_1_3_3_149_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13020279"},{"key":"e_1_3_3_150_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0721-9"},{"key":"e_1_3_3_151_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1436499"},{"key":"e_1_3_3_152_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911037"},{"key":"e_1_3_3_153_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00371"},{"key":"e_1_3_3_154_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-025-06910-y"},{"key":"e_1_3_3_155_2","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2024.2422004"},{"key":"e_1_3_3_156_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2023.2214316"},{"key":"e_1_3_3_157_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2022.101714"},{"key":"e_1_3_3_158_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001439"},{"key":"e_1_3_3_159_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.893015"},{"key":"e_1_3_3_160_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.6614"},{"key":"e_1_3_3_161_2","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2020.1817380"},{"key":"e_1_3_3_162_2","doi-asserted-by":"publisher","DOI":"10.1177\/0253717621992372"},{"key":"e_1_3_3_163_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S501111"},{"key":"e_1_3_3_164_2","first-page":"79","volume-title":"Side effects of drugs annual","author":"Sobolewski K","year":"2021","unstructured":"Sobolewski K. Sedatives and hypnotics. In: Ray SD (eds) Side effects of drugs annual. Elsevier, 2021, pp.79\u201387."}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261461161","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261461161","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261461161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:42:06Z","timestamp":1791808926000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261461161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":163,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/13872877261461161"],"URL":"https:\/\/doi.org\/10.1177\/13872877261461161","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]}}}