{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:20:48Z","timestamp":1788254448162,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100015499","name":"Jeonbuk National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015499","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Amyloid-\u03b2 (A\u03b2) pathology is a core feature of Alzheimer's disease (AD) and may be present in mild cognitive impairment (MCI). Accessible, non-invasive markers of early A\u03b2-related cognitive change are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether perceptual-phase eye-tracking metrics during figure copying are associated with A\u03b2-PET positivity in MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this cross-sectional study, 59 patients with MCI underwent\n                      <jats:sup>18<\/jats:sup>\n                      F-flutemetamol PET and were classified as A\u03b2-PET positive (n\u2009=\u200934) or A\u03b2-PET negative (n\u2009=\u200925). Participants completed a simplified Rey-Osterrieth Complex Figure Test while wearing eye-tracking glasses. The display was then divided into perceptual and working areas of interest (AOIs), and metrics were extracted for each AOI. A matched-pair sensitivity analysis (n\u2009=\u200928) was performed to reduce differences in age, education, and Mini-Mental State Examination scores. Binary logistic regression was used to examine the association between A\u03b2-PET positivity and fixation duration in the perceptual AOI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The A\u03b2-PET positive group showed significantly longer fixation duration in the perceptual AOI (p\u2009=\u20090.027, r\u2009=\u20090.296), whereas no significant group differences were observed in the working AOI. Exploratory analyses showed higher fixation count, visit duration, visit count, and saccade count in the perceptual AOI of the A\u03b2-PET-positive group. Longer fixation duration in the perceptual AOI was independently associated with A\u03b2 positivity (OR per second\u2009=\u20091.18, 95% CI 1.03\u20131.36, p\u2009=\u20090.021).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A\u03b2-PET positivity in MCI was associated with greater perceptual-phase gaze inefficiency during figure copying. Perceptual-phase eye-tracking metrics may serve as potential markers of amyloid-related visuospatial alteration in MCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261461540","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:33:22Z","timestamp":1782311602000},"page":"279-290","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Perceptual-phase eye-tracking during figure copying is associated with amyloid-\u03b2 PET positivity in mild cognitive impairment"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1321-828X","authenticated-orcid":false,"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Jeonbuk National University Medical School and Hospital"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-845X","authenticated-orcid":false,"given":"Yutong","family":"Bai","sequence":"additional","affiliation":[{"name":"Jeonbuk National University Medical School and Hospital"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3033-0014","authenticated-orcid":false,"given":"Byoung-Soo","family":"Shin","sequence":"additional","affiliation":[{"name":"Jeonbuk National University Medical School and Hospital"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4564-9714","authenticated-orcid":false,"given":"Ko Woon","family":"Kim","sequence":"additional","affiliation":[{"name":"Jeonbuk National University Medical School and Hospital"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.854368"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.158"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.053014"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab035"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1217746"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2016.31.2.286"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.590986"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215551"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-015-9283-z"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11111503"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.3567"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13478"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49275-x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00377"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv103"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2196\/18136"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.844341"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151026"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004826"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2019.18.3.77"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2021.20.3.28"},{"key":"e_1_3_3_23_2","first-page":"189","article-title":"A study on the reliability and validity of Seoul-Instrumental Activities of Daily Living (S-IADL)","volume":"43","author":"Ku H-M","year":"2004","unstructured":"Ku H-M, Kim J-H, Kwon E-J, et al. 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