{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:51:36Z","timestamp":1791809496800,"version":"4.3.4"},"reference-count":59,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171400"],"award-info":[{"award-number":["82171400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271441"],"award-info":[{"award-number":["82271441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Huangpu District Health System Professional Talent Training Project","award":["2023XD01"],"award-info":[{"award-number":["2023XD01"]}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["21QA1405800"],"award-info":[{"award-number":["21QA1405800"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The National Key Research and Development Program of China, Scientific and technological innovation 2030 - \u201cBrain science\u201d","award":["2022ZD0213800"],"award-info":[{"award-number":["2022ZD0213800"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Changes in sleep characteristics are critical in the course of Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to explore the relationship between sleep duration and tau pathology progression in patients with AD and mild cognitive impairment (MCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included 172 patients (70 with MCI and 102 with AD). Sleep duration and disturbances were assessed through standardized questionnaires, while tau deposition and cerebrospinal fluid clearance were evaluated using tau-PET and diffusion tensor image analysis along the perivascular space (DTI-ALPS), along with comprehensive cognitive assessments. The data were adjusted for variables such as demographic factors, clinical symptoms, and medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sleep duration showed a positive association with tau deposition in the MCI stage (total sleep: \u03b2\u2009=\u20090.18, p\u2009=\u20090.014; nighttime sleep: \u03b2\u2009=\u20090.20, p\u2009=\u20090.007) but negatively associated in the AD stage (total sleep: \u03b2\u2009=\u2009\u22120.18, p\u2009=\u20090.039; nighttime sleep: \u03b2\u2009=\u2009\u22120.20, p\u2009=\u20090.039). Patients with sleep disturbances demonstrated lower tau burdens (group difference\u2009=\u20090.62, p\u2009=\u20090.005). Mediation analysis revealed a significant indirect effect of depression in the sleep-tau relationship (total sleep: \u03b2\u2009=\u2009\u22120.26, p\u2009=\u20090.040; nighttime sleep: \u03b2\u2009=\u2009\u22120.24, p\u2009=\u20090.040).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study first revealed the stage-dependent characteristics of sleep-tau relationships, highlighting the MCI stage as a critical research focus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial<\/jats:title>\n                    <jats:p>\n                      The study was registered with ClinicalTrials.gov (NCT05623124). URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT05623124\">https:\/\/clinicaltrials.gov\/study\/NCT05623124<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261462419","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:44:47Z","timestamp":1782913487000},"page":"1931-1944","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stage-dependent relationship between sleep duration and cortical tau deposition in cognitively impaired individuals: A cross-sectional study"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9061-6404","authenticated-orcid":false,"given":"Yingting","family":"Zheng","sequence":"first","affiliation":[{"name":"Ruijin Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Kang","sequence":"additional","affiliation":[{"name":"Ruijin Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Ruijin Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Ruijin Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Ruijin Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Ruijin Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Ruijin Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Ruijin Hospital"},{"name":"Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyin","family":"Li","sequence":"additional","affiliation":[{"name":"Ruijin Hospital"},{"name":"Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9564-2609","authenticated-orcid":false,"given":"Yulei","family":"Deng","sequence":"additional","affiliation":[{"name":"Ruijin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. 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