{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:51:23Z","timestamp":1791809483757,"version":"4.3.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","award":["2024A4025"],"award-info":[{"award-number":["2024A4025"]}],"id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lecanemab is an anti-amyloid monoclonal antibody, approved for early Alzheimer's disease (AD), with evidence indicating greater benefit at earlier stages. Sensitive cognitive measures are needed to identify underlying amyloid pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether the Logical Memory (LM) subtest of the Wechsler Memory Scale-Revised (WMS-R) can help characterize amyloid positivity in lecanemab-eligible individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 91 individuals who attended our center between December 2023 and March 2025; 45 met eligibility criteria (Mini-Mental State Examination \u2265 22, Clinical Dementia Rating 0.5 or 1.0, magnetic resonance imaging compatibility). Amyloid status was determined by positron emission tomography, classified as amyloid-positive (A\u03b2+, n\u2009=\u200935) or amyloid-negative (A\u03b2\u2212, n\u2009=\u200910). All participants underwent neuropsychological assessment, including LM. Groups were compared, and LM A\u03b2 status discrimination was evaluated using receiver operating characteristic analyses and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Groups did not differ in age, sex, or education. LM immediate (LMIR) and delayed recall (LMDR) scores were lower in the A\u03b2+ group (LMIR median: 5.0 versus 9.0, p\u2009=\u20090.011; LMDR: 0.5 versus 3.0, p\u2009=\u20090.017). Receiver operating characteristic analyses identified cutoffs of 7.5 for LMIR (area under the curve [AUC]: 0.79, sensitivity: 79%, specificity: 77%) and 1.5 for LMDR (AUC: 0.76, sensitivity: 75%, specificity: 77%). Lower LM scores were associated with increasing amyloid positivity. Logistic regression showed significant associations for both LMIR and LMDR (odds ratio: 0.80 and 0.64, 95% confidence interval: 0.64\u20130.95 and 0.38\u20130.91, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>WMS-R LM scores were significantly associated with amyloid-\u03b2 accumulation in individuals with early AD meeting lecanemab eligibility criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261462928","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:11:04Z","timestamp":1782558664000},"page":"1879-1886","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Logical memory is associated with amyloid-\u03b2 positivity in patients with early Alzheimer's disease eligible for lecanemab"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6755-3569","authenticated-orcid":false,"given":"Naoko","family":"Kawabe","sequence":"first","affiliation":[{"name":"Kobe City Medical Center General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-3677","authenticated-orcid":false,"given":"Satoshi","family":"Hosoki","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruko","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunitaka","family":"Matsuishi","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3571-6370","authenticated-orcid":false,"given":"Kentaro","family":"Iwata","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Kohara","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital"},{"name":"Kobe City Medical Center General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michi","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Kobe City Medical Center General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5847"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130881"},{"key":"e_1_3_3_7_2","volume-title":"Wechsler Memory Scale\u2013Revised manual","author":"Wechsler D","year":"1987","unstructured":"Wechsler D. Wechsler Memory Scale\u2013Revised manual. San Antonio, TX: The Psychological Corporation, 1987."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215364"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-025-01778-8"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.908651"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_3_3_13_2","unstructured":"Ministry of Health Labour and Welfare (Japan). Proper Use Guide for Lecanemab (genetically modified). https:\/\/www.mhlw.go.jp\/stf\/shingi2\/0000212500_00231.html (2023 accessed 22 June 2025)."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0910-3"},{"key":"e_1_3_3_15_2","volume-title":"Appropriate Use Guideline for Amyloid PET Imaging Agents, 4th edn","author":"Working Group on the Appropriate Use of Amyloid PET Imaging Agents","year":"2025","unstructured":"Working Group on the Appropriate Use of Amyloid PET Imaging Agents. Appropriate Use Guideline for Amyloid PET Imaging Agents, 4th edn. Tokyo: Japanese Society of Nuclear Medicine, 2025. https:\/\/jsnm.org\/archives\/655\/ (accessed 13 July 2025)."},{"key":"e_1_3_3_16_2","first-page":"215","article-title":"L\u2019examen psychologique dans les cas d\u2019enc\u00e9phalopathie traumatique","volume":"28","author":"Rey A","year":"1941","unstructured":"Rey A. L\u2019examen psychologique dans les cas d\u2019enc\u00e9phalopathie traumatique. Arch Psychol 1941; 28: 215\u2013285.","journal-title":"Arch Psychol"},{"key":"e_1_3_3_17_2","volume-title":"Trail Making Test, Japanese edition","author":"Japanese Society for Higher Brain Dysfunction","year":"2019","unstructured":"Japanese Society for Higher Brain Dysfunction. Trail Making Test, Japanese edition. Tokyo: Shinko Igaku Publishing, 2019."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1621"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.1353"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2008.02.008"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000334295"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2214"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1996.tb05866.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010461107"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01150-x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.031"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.01.051"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.06.041"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12141"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/107319119700400111"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12007"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261462928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261462928","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261462928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:43:55Z","timestamp":1791809035000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261462928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,27]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/13872877261462928"],"URL":"https:\/\/doi.org\/10.1177\/13872877261462928","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,27]]}}}